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| RP-HPLC双波长同时测定关节止痛膏中硫酸阿托品、盐酸苯海拉明、辣椒碱和二氢辣椒碱的含量 | |
| 引用本文： | 贾晓斌,刘齐,韦英杰,陈斌,储益平,张家铭. RP-HPLC双波长同时测定关节止痛膏中硫酸阿托品、盐酸苯海拉明、辣椒碱和二氢辣椒碱的含量[J]. 中国中药杂志, 2010, 35(21): 2838-2841 |
| 作者姓名： | 贾晓斌 刘齐 韦英杰 陈斌 储益平 张家铭 |
| 作者单位： | 1. 江苏省中医药研究院国家中医药管理局中药口服释药系统重点研究室,江苏南京,210028;江苏大学药学院,江苏镇江,212013 2. 江苏省中医药研究院国家中医药管理局中药口服释药系统重点研究室,江苏南京,210028 3. 常州市盛辉药业有限公司,江苏常州,213000 |
| 基金项目： | 国家"十一五"科技支撑计划项目(2008BAI53B072) |
| 摘 要： | 目的:建立用高效液相色谱同时测定关节止痛膏中主要药效成分硫酸阿托品、盐酸苯海拉明、辣椒碱及二氢辣椒碱的含量。方法:采用RP-HPLC双波长法,色谱柱Alltima C18(4.6 mm×250 mm,5μm);流动相乙腈-0.1%磷酸,梯度洗脱程序;体积流量1 mL.min-1;检测波长210,280 nm;柱温30℃。结果:硫酸阿托品在2.01~50.25 mg.L-1,盐酸苯海拉明在15.08~377.00 mg.L-1,辣椒碱在5.02~125.50 mg.L-1,二氢辣椒碱在5.03~125.75 mg.L-1与峰面积呈良好的线性关系。加样回收率分别为99.00%(RSD 0.95%),99.89%(RSD 1.2%),100.13%(RSD 1.5%),99.51%(RSD 1.4%)。结论:此方法准确、快速分析关节止痛膏中4种主要成分,灵敏度高,重复性好,可控制关节止痛膏的质量。 |
| 关 键 词： | 关节止痛膏 反相高效液相色谱 硫酸阿托品 盐酸苯海拉明 辣椒碱 二氢辣椒碱 |
| 收稿时间： | 2010-06-17 |
Simultaneously determination of atropine sulphate,diphenhydramine hydrochloride, capsaicin and dihydrocapsaicin in pain-relieving plaster for arthritis by RP-HPLC |
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| JIA Xiaobin,LIU Qi,WEI Yingjie,CHEN Bin,CHU Yiping and ZHANG Jiaming. Simultaneously determination of atropine sulphate,diphenhydramine hydrochloride, capsaicin and dihydrocapsaicin in pain-relieving plaster for arthritis by RP-HPLC[J]. China Journal of Chinese Materia Medica, 2010, 35(21): 2838-2841 | |
| Authors: | JIA Xiaobin LIU Qi WEI Yingjie CHEN Bin CHU Yiping ZHANG Jiaming |
| Affiliation: | Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Department of Pharmaceutics, Jiangsu University, Zhenjiang 212013;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Department of Pharmaceutics, Jiangsu University, Zhenjiang 212013;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Shenghui Medicinal Science and Technology Consulting Co., Ltd., Changzhou 213000, China;Shenghui Medicinal Science and Technology Consulting Co., Ltd., Changzhou 213000, China |
| Abstract: | |
| Keywords: | pain-relieving plaster for arthritis RP-HPLC atropine sulphate diphenhydramine hydrochloride capsaicin dihydrocapsaicin |
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