冠心病合并糖尿病患者介入治疗后炎性因子与冠状动脉病变进展的关系

目的探讨冠心病合并糖尿病患者冠状动脉介入治疗(PCI)后血清炎性因子超敏C-反应蛋白(hs-CRP)、可溶性细胞间黏附分子1(sICAM-1)、白细胞介素-6(IL-6)与冠状动脉病变进展的关系。方法将89例PCI后再次行冠状动脉造影(CAG)患者分为糖尿病组42例和非糖尿病组47例,测定其血清hs-CRP、sICAM-1、IL-6水平;采用Gensini评分系统,对PCI后和再次CAG进行评分,计算2次积分差值。结果糖尿病组患者血清hs-CRP、sICAM-1、IL-6的浓度和Gensini评分差值均显著高于非糖尿病组(P<0.01);hs-CRP、sICAM-1、IL-6与Gensini评分差值呈正相关(r分别为0.497、0.513、0.548,P均<0.05)。结论 PCI术后冠状动脉病变进展与炎性反应程度相关;冠心病合并糖尿病患者炎性反应更强,PCI术后冠状动脉病变进展更快。

Correlation between inflammatory cytokines and progress of coronary artery disease in patient with coronary heart disease complicated with diabetes after percutanous coronary intervention

Objective To discuss the correlation between high-sensitivity C-reactive protein(hs-CRP) ,soluble intercellular adhesion molecule1(sICAM-1) ,interleukin-6(IL-6) and progress of coronary artery disease in patient with coronary heart disease complicated with diabetes after percutanous coronary intervention(PCI) .Methods 89 cases patients were divided into diabetes group(n=42) and non-diabetes group(n=47) ,determined hs-CRP,sICAM-1 and IL-6 of two groups;Using Gensini scoring system,to after PCI and again coronary angiography(CAG) marked,calculated the difference between 2 points.Results The concentration of serum hs-CRP,sICAM-1,IL-6 and Gensini difference score of diabetes group were significantly higher than those of non-diabetic group(P<0.01) ;hs-CRP,sICAM-1,IL-6 and Gensini difference score were positively correlated(r=0.497,0.513,0.548,P<0.05) .Conclusion Progress of coronary artery disease after PCI level associated with the inflammatory response;In patient with coronary heart disease complicated with diabetes,as stronger inflammatory response,after PCI progress of coronary artery lesions is faster.