短期人胰岛素类似物强化降糖治疗初诊2型糖尿病的疗效

目的观察并比较赖脯胰岛素联合甘精胰岛素与胰岛素泵强化治疗初诊高血糖2型糖尿病(T2DM)的疗效及效价。方法将60例初诊T2DM患者随机分为观察组和对照组各30例。观察组三餐前皮下注射赖脯胰岛素联合睡前皮下注射甘精胰岛素;对照组三餐前胰岛素泵持续皮下注射重组人胰岛素。记录并比较2组血糖控制及达标时间、每日胰岛素用量、成本及低血糖发生情况。结果 2组强化治疗后血糖均低于治疗前,差异有统计学意义(P<0.01);但组间比较差异无统计学意义(P>0.05)。2组血糖达标时间、胰岛素用量、低血糖发生率比较差异无统计学意义(P>0.05)。A组平均降糖费用低于对照组,差异有统计学意义(P<0.01)。结论短期人胰岛素类似物皮下注射用于初诊血糖过高的T2DM患者疗效确切,是一种经济、安全、可靠的强化治疗方案。

Effect of the short-term intensive therapy of insulin analogue combination treatment of newly diagnosed type 2 diabetic patients

Objective To observe the effects and the cost of the combination of insulin glargine with insulin lispro treatment and insulin pump treatment in newly diagnosed type 2 diabetic patients with severe hyperglycemia.Methods 60 newly diagnosed type 2 diabeticpatients with severe hyperglycemia were divided into observation group and control group in random,with 30 patients in each group.The observation group was treated with insulin lispro subcutaneous injections before meals and the insulin glargine subcutaneous injections at bedtime.The control group was treated with continuous subcutaneous insulin infusion and a dose of injection before each meal by insulin pump.The blood glucose,the incidence rate of hypoglycemia,time and cost which spent to make the blood glucose up to the standard,daily insulin doses after treatment were compared.Results Blood glucose in the two groups were significantly decreased,and the difference was significant（P0.01）.There were no significant difference between two groups in blood glucose,insulin doses,and time when the blood glucose up to the standard after treatment（P0.05）,but the cost of control group was obviously higher than that of observation group（P0.01）.Conclusion Treatment by the combination of insulin glargine and insulin lispro in newly diagnosed type 2 diabetic patients has the similar effects to insulin pump therapy,but the money spent is cheaper.