小儿轮状病毒肠炎致全身炎症反应综合征IL-2、IL-6及TNF的变化及意义

目的观察轮状病毒肠炎致全身炎症反应综合征（SIRS）患儿血清白细胞介素-2（IL-2）、白细胞介素-6（IL-6）及肿瘤坏死因子（TNF）的变化。方法对78例轮状病毒肠炎患儿（其中40例SIRS患儿，38例非SIRS患儿）及健康对照组（43例）测定血清IL-2、IL-6及TNF的变化；对其中40例SIRS患儿治疗前后的IL-2、IL-6及TNF的变化进行比较。结果SIRS患儿血清IL-6及TNF含量明显高于非SIRS组和对照组，SIRS患儿血清IL-2含量明显低于非SIRS组和对照组，有显著性差异（P〈0．01）。在SIRS患儿中随着异常指标的增加，IL-6、TNF升高，IL-2降低愈明显（P〈0．01）。SIRS患儿经治疗，IL-6、TNF升高，IL-2降低明显好转。结论对SIRS的合理治疗对IL-6、TNF升高，IL-2降低有显著的逆转作用。

Changes and Significance of Serum Interleukin-2,6 and Tumor Necrosis Factor in Systemic Inflammatory Syndrome Induced by Children's Rotavirus Enteritis

Objective To observe the changes of serum interleukin -2,6 （IL -2,6 ）and tumor necrosis factor（ TNF） in systemic inflammatory response syndrome（SIRS） induced by children＇s rotavirus enteritis. Methods Serum IL - 2, IL - 6 and TNF were detected in 78 children with rotavirus enteritis （ of which,40 cases were SIRS and 38 cases were non -SIRS）, as well as in health control group（43 children）. The changes of IL - 2, IL - 6 and TNF before and after treatment were compared among 40 cases with SIRS. Results Serum IL - 6 and TNF levels in SIRS group were higher apparently than those in non - SIRS groups and control group, and IL -2 level in SIRS group was lower apparently than that in non - SIRS groups and control group, indicating significant differences in comparison（ P 〈 0.01 ）. In SIRS group, the more the abnormal indexes were, the more apparently IL -6 and TNF were increased and IL -2 decreased （P 〈 0.01 ）. After treatment in SIRS group, the increase of IL -6 and TNF and decrease of LI -2 were relieved apparently. Conclusion Rational treatment reverses the increased IL -6 and TNF and decreased IL -2 significantly in SIRS.