Interferon induces an antiviral state in ganglioside-deficient transformed mouse fibroblasts |
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Authors: | D Schiffmann K Koschel |
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Institution: | (1) Institut für Virologie und Immunobiologie der Universität Würzburg, Versbacher Landstraße 7, D-8700 Würzburg, Federal Republic of Germany |
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Abstract: | The antiviral activity of mouse fibroblast interferon against vesicular stomatitis virus was investigated in L-929 mouse fibroblasts and the ganglioside-deficient L-929 mutant cells (ATCC clone NCTC 2071). Although it has been widely reported that gangliosides serve as primary receptors for interferon at the cellular membrane, only a small difference in interferon sensitivity was observed between the wild-type L-929 and the ganglioside-deficient NCTC 2071 cells. It was not possible, however, to overcome this difference by administration of exogenous gangliosides. |
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