应用群体药动学模型制订患儿抗癫痫给药方案的药学会诊实践

目的 为优化癫痫患儿卡马西平和丙戊酸给药方案提供参考。方法 药师参与1例脑外伤术后癫痫患儿的药学会诊，总结分析其使用卡马西平和丙戊酸血药浓度异常的原因，应用群体药动学模型为患儿调整给药剂量，并评价笔者团队所建模型的预测能力。结果 患儿病情得到了有效控制。结论 药师应用群体药动学模型优化抗癫痫药物治疗方案，为临床合理用药提供参考。

Practice of pharmacy consultation on dosage regimen for pediatric epilepsy patient with PPK model

Objective In order to provide a reference for optimizing the dosage regimen of carbamazepine and valproate in pediatric epilepsy patients.Methods Pharmacist consulted one pediatric epilepsy patient with traumatic brain injury for post operation epilepsy treatments. The abnormal plasma concentration of carbamazepine and valproic acid was analyzed with the population pharmacokinetic (PPK) model built by this team. New medication regimen was proposed and the predictive capability of this model was evaluated.Results Seizures in this patient have been effectively controlled. Conclusion Pharmacist can optimize the antiepileptic drug treatment with PPK model and achieve rational drug use clinically.