| 放射性125I粒子胃管治疗晚期食管癌10例临床分析 |
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| 引用本文： | 孙文,牛洪欣,张西坤,王斌,杨焕刚,仲锋,孙琳,汪建,郝亮,宋文韬.放射性125I粒子胃管治疗晚期食管癌10例临床分析[J].中华放射医学与防护杂志,2017,37(10):752-757. |
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| 作者姓名： | 孙文 牛洪欣 张西坤 王斌 杨焕刚 仲锋 孙琳 汪建 郝亮 宋文韬 |
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| 作者单位： | 250200, 济南大学 山东省医学科学院医学与生命科学学院,250031 济南, 山东省医学科学院附属医院微创外科,250031 济南, 山东省医学科学院附属医院微创外科,250031 济南, 山东省医学科学院附属医院微创外科,250031 济南, 山东省医学科学院附属医院微创外科,250031 济南, 山东省医学科学院附属医院微创外科,250031 济南, 山东省医学科学院附属医院微创外科,250031 济南, 山东省医学科学院附属医院微创外科,250031 济南, 山东省医学科学院附属医院微创外科,250031 济南, 山东省医学科学院附属医院微创外科 |
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| 基金项目： | 山东省科技发展计划项目（2014GSF118182） |
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| 摘 要： | 目的 探讨放射性125I粒子胃管治疗晚期食管癌的可行性、安全性及初步疗效。方法 选择10例晚期食管癌患者，根据术前CT影像，在治疗计划系统中勾画肿瘤靶区，处方剂量60 Gy，粒子放射性活度2.22×107 Bq，估算出125I粒子数，选择合适的胃管，根据肿瘤位置于胃管外周按一定的规律固定上125I粒子，制成粒子胃管。在C臂X射线透视下将其置入到患者食管内肿瘤部位，并随访。结果 10例患者125I粒子胃管均顺利置入，未出现食管穿孔、出血等并发症，且术后均未出现胸痛、出血、肺炎等相关并发症。术后1个月所有患者的吞咽困难， Stooler 分级评分均为2~3级，其中1例在术后3个月死于其他基础疾病，6例在术后4个月时吞咽困难， Stooler 分级评分达到0~1级，3例达到1~2级。结论 放射性125I粒子胃管既能提供鼻饲，解决营养问题，又能腔内照射肿瘤，抑制肿瘤生长，临床使用是安全、可行的，可作为晚期食管癌患者的一种姑息性治疗手段。
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| 关 键 词： | 食管癌 125I粒子 胃管 腔内照射 |
| 收稿时间： | 2017/4/6 0:00:00 |
Clinical analysis of 10 cases of advanced esophageal carcinoma treated with radioactive gastric tube of 125I seeds |
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| Sun Wen,Niu Hongxin,Zhang Xikun,Wang Bin,Yang Huangang,Zhong Feng,Sun Lin,Wang Jian,Hao Liang and Song Wentao.Clinical analysis of 10 cases of advanced esophageal carcinoma treated with radioactive gastric tube of 125I seeds[J].Chinese Journal of Radiological Medicine and Protection,2017,37(10):752-757. |
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| Authors: | Sun Wen Niu Hongxin Zhang Xikun Wang Bin Yang Huangang Zhong Feng Sun Lin Wang Jian Hao Liang and Song Wentao |
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| Institution: | School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250200, China,Department of Minimally Invasive Surgery, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan 250031, China,Department of Minimally Invasive Surgery, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan 250031, China,Department of Minimally Invasive Surgery, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan 250031, China,Department of Minimally Invasive Surgery, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan 250031, China,Department of Minimally Invasive Surgery, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan 250031, China,Department of Minimally Invasive Surgery, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan 250031, China,Department of Minimally Invasive Surgery, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan 250031, China,Department of Minimally Invasive Surgery, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan 250031, China and Department of Minimally Invasive Surgery, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan 250031, China |
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| Abstract: | |
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| Keywords: | Esophageal carcinoma 125I seed Gastric tube Intracavitary brachytherapy |
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