骨形态发生蛋白在颅颌面外科的应用及展望

面部骨骼发育畸形、骨缺损、骨不连等的修复重建是颅面外科的主要内容。目前,颅面部骨骼修复重建治疗的手段不外乎手术截骨重排结合骨修复材料植入。随着细胞生物学研究的不断深入,及对颅面部骨骼生长发育的深入认识,越来越多的研究表明生长因子在骨骼修复重建中广泛参与骨骼组织再生重建的局部调节,其中骨形态发生蛋白家族(Bone Morphogenetic Proteins,BMPs)是研究热点之一。本文对BMPs概况、促成骨作用机制、动物实验、初步临床应用等方面进行综述,为今后BMPs在颅面骨骼修复重建领域的进一步研究和应用提供一定的理论依据。

The Applications and Prospects of Bone Morphogenetic Proteins (BMPs) in Craniofacial Surgery

The repair and reconstruction of facial bone deformities, bone defects, nonunion due to all causes are concerned in the craniofacial surgical work. Craniofacial bone are repaired and reconstructed mainly by means of osteotomy, bone-rearrangement combined with repair materials implantation. With the progress of cell biology and in-depth knowledge of the growth and development of craniofacial skeleton, a growing number of studies have shown that growth factors widely participate in the bone repair and reconstruction in the local regulation of bone tissue regeneration. The bone morphogenetic protein s (BMPs) is one of the focus. In this paper, the BMPs overview, the mechanism of promoting bone formation, animal experiments, preliminary clinical experience and many other aspects were reviewed to provide a theoretical basis for further research and the application of BMPs in the repair of craniofacial bone and reconstruction in the future.