肿瘤患者真菌感染的菌株分布及耐药性分析

目的分析肿瘤患者真菌感染的菌株分布及耐药情况,以便更好地指导临床预防及治疗真菌感染。方法回顾性分析2008年1月至2009年12月从住院肿瘤患者送检标本中分离出的258株真菌的分布及耐药情况。结果 258例真菌感染以痰标本为主,占45.74%;真菌种类以白色假丝酵母菌占首位,为54.26%,其次为热带假丝酵母菌15.89%;真菌药敏试验结果表明,真菌对两性霉素B耐药率为0;对伊曲康唑和伏立康唑耐药率为8.3%～23.3%;对氟康唑耐药率为15.7%～96.7%。结论肿瘤患者并发真菌感染以白假丝酵母菌为主,热带假丝酵母菌、克柔假丝酵母菌感染率较高。临床应及时掌握肿瘤患者治疗过程中引起真菌感染病原菌的分布及耐药情况,为合理应用抗真菌药物提供依据。

Analysis of the fungal distrubition and drug-resistance in tumor patients with fungal infection

Objective To determine the characteristics of chinical distribution and drug-resistance of 258 fungal strains for providing the bases for chinical therapy.Methods 258 strains,which were isolated from tumor patients in our hospital from Jan,were retiospectively analyzed.2008 to Dec.2009.Results Mucus was the main infection（45.74%）;in terms of the types of fungus,candida albicans occupied the first place（54.26%）,next was C.tropicalis（15.89%）;The susceptibility test showed that the drug-resistance rate to amphotericin B was zero and to itraconazole and voriconazole was 8.3% and 23.3% respectively.The resistance rate to fluconazole was 15.89%~96.7%.Conclusion Candida albicans is the major fungus in patients with tumor,and the infection rate of C.tropicalis and C.krusei is also high.Clinical doctors should control the distribution and drug resistance of fungal infection in therapeutic process for a reasonable use of antibiotics usage.