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固尔苏治疗NRDS前后血管内皮分泌功能的改变
引用本文:周曙明,丘惠娴,刘红,封志纯. 固尔苏治疗NRDS前后血管内皮分泌功能的改变[J]. 中国妇幼保健, 2003, 18(5): 298-299
作者姓名:周曙明  丘惠娴  刘红  封志纯
作者单位:1. 深圳市龙岗中心医院儿科,518116
2. 第一军医大学珠江医院儿科
基金项目:深圳市卫生局科研项目 (2 0 0 2 0 4 1 4 2 )
摘    要:目的 :研究肺表面活性物质 (PS)治疗新生儿呼吸窘迫综合征 (NRDS)前后血管内皮分泌功能变化及可能的治疗机理。方法 :用PS制剂固尔苏治疗 18例NRDS患儿 ,于治疗前 3 0min ,治疗后 1、 6、 12、 2 4h ,用硝酸还原酶法测定NO (一氧化氮 )、放射免疫法测定ET (内皮素 )、 6 K PGF1α (6 酮前列环素 )。结果 :固尔苏治疗后患儿NO、 6 K PGF1α明显升高 ,ET明显下降 ,与治疗前比较有显著性差异 (P <0 0 1)。治疗后 1、 6、 12、 2 4hNO、6 k PGF1α、ET各组间两两比较无明显差异 (P >0 0 5 )。结论 :PS治疗NRDS的机理可能是通过改善血管内皮功能发挥作用 ,为用外源性NO吸入和静注前列环素辅助治疗NRDS提供可能的实验依据。

关 键 词:肺表面活性物质  新生儿呼吸窘迫综合征  内皮素  一氧化氮  前列环素
修稿时间:2003-02-01

The change of secreted function of vascular endothelia before and after NRDS treated by Guersu
Zhou Shu Ming,Qiu Hui Xian,Liu Hong et al. Pediatric. The change of secreted function of vascular endothelia before and after NRDS treated by Guersu[J]. Maternal and Child Health Care of China, 2003, 18(5): 298-299
Authors:Zhou Shu Ming  Qiu Hui Xian  Liu Hong et al. Pediatric
Affiliation:Zhou Shu Ming,Qiu Hui Xian,Liu Hong et al. Pediatric Department of Longgang Hospital of Shenzhen
Abstract:Objective: To study the change of secreted function of vascular endothelia before and after Newborn Respiratory Distress Syndrome (NRDS) was treated by pulmonary surface active substance (PS) and the principle. Methods: In 30 min before 18 cases NRDS children were treated by PS ,and 1,6,12,24 hours after treatment , NO was measured by nitric acid restore enzyme method, ET and 6 K PGF1α were measured by radiate immune method. Results: NO and 6 K PGF1α were increased evidently after treatment. ET was decreased evidently, there was significant difference comparing with pretreatment ( P <0 01). NO, 6 K PGF1α ,ET didn't have significant difference in each groups ( P >0 05). Conclusion: The principle of PS treating NRDS might be its improving vascular endothelia and it provide study evident for NO absorbance and i.v. PGF1α for NRDS treatment .
Keywords:Pulmonary surface active substance   Newborn Respiratory Distress Syndrome   Endothelia  NO  PGF1α
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