| 连萸总生物碱胃滞留双室渗透泵片的制备及体外释放度考察 |
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| 作者姓名： | Fang Y Shi QW |
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| 作者单位： | 河北医科大学药学院; |
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| 摘 要： | 目的:对连萸总生物碱胃滞留双室渗透泵片(TCOPT)的制备方法进行研究,并考察其体外释放度。方法:以释放度为评价指标,采用正交设计实验优化处方与工艺。结果:最佳处方为:膨胀剂为PEO(Mw 5000000)与HPMC混合物(4∶1),用量50 mg,助推层渗透剂氯化钠用量为20 mg,包衣液致孔剂PEG 400用量10%,包衣增重9%。释药行为符合零级方程,具有明显的控释特征。结论:TCOPT具有良好的体外控释效果,可进一步进行体内释药行为考察。
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| 关 键 词： | 黄连 吴茱萸 双室渗透泵片 胃滞留 体外释放 |
Studies on preparation and dissolution test in vitro of intragastric floating two-chamber osmotic pump tablets of total alkaloids of Coptis chinensis and Evodia rutaecarpa |
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| Fang Y,Shi QW.Studies on preparation and dissolution test in vitro of intragastric floating two-chamber osmotic pump tablets of total alkaloids of Coptis chinensis and Evodia rutaecarpa[J].Jorunal of Chinese Medicinal Materials,2011,34(5):779-782. |
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| Authors: | Fang Yu Shi Qing-Wen |
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| Institution: | FANG Yu,SHI Qing-wen(Pharmacy faculty of Hebei medical university,Shijiazhuang 050017,China) |
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| Abstract: | |
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| Keywords: | Coptis chinensis Evodia rutaecarpa Two-chamber osmotic pump tablets Intragastric floating Release in vitro |
| 本文献已被 CNKI PubMed 等数据库收录！ |
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