| PVP对大豆苷元溶出度和生物利用度的影响(英文) |
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| 引用本文： | 冯宝璐,李汉文,周明瑶,卢闻.PVP对大豆苷元溶出度和生物利用度的影响(英文)[J].中药材,2011(4). |
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| 作者姓名： | 冯宝璐 李汉文 周明瑶 卢闻 |
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| 作者单位： | 西安交通大学医学院; |
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| 基金项目： | 国家自然科学基金(30730110) |
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| 摘 要： | 目的:考察以聚乙烯吡咯烷酮为载体制备固体分散体对大豆苷元溶解度、溶出度和生物利用度的改善。方法:溶剂法制备大豆苷元固体分散体,差示量热法、傅立叶红外、平衡溶解度法、溶出度法考察固体分散体的性质;小鼠血浆动力学比较大豆苷元固体分散体和大豆苷元的生物利用度。结果:以聚乙烯吡咯烷酮为载体的固体分散技术将大豆苷元的溶解度提高了8倍,且明显增加了其溶出度;提高了大豆苷元在小鼠血浆中的达峰浓度和曲线下面积。结论:以聚乙烯吡咯烷酮为载体的固体分散技术可提高大豆苷元在小鼠体内的生物利用度。
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| 关 键 词： | 大豆苷元 聚乙烯吡咯烷酮 固体分散体 溶出度 生物利用度 |
Dispersion of Daidzein with Polyvinylpyrrolidone Effects on Dissolution Rate and Bioavailability |
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| FENG Bao-lu,LI Han-wen,ZHOU Ming-yao,LU Wen.Dispersion of Daidzein with Polyvinylpyrrolidone Effects on Dissolution Rate and Bioavailability[J].Jorunal of Chinese Medicinal Materials,2011(4). |
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| Authors: | FENG Bao-lu LI Han-wen ZHOU Ming-yao LU Wen |
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| Abstract: | Objective:To study on the dispersion of daidzein with polyvinylpyrrolidone(PVP)and its effects on the aqueous solubility,dissolution rate and bioavailability of daidzein.Methods:The solid dispersion of daidzein at various daidzein to PVP ratios were obtained via the solvent evaporation method and characterized by differential scanning calorimetry and fourier transform infrared spectroscopy.In addition,the bioavailability of free daidzein as well as its solid dispersion were studied in mice.Results:It was fo... |
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| Keywords: | Daidzein Polyvinylpyrrolidone Solid dispersion Dissolution Bioavailability |
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