| 阿魏酸对bFGF诱导PC12细胞分化的影响 |
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| 引用本文： | Lin LF,Xiao F,Lai YC,Su JN,Luo HM. 阿魏酸对bFGF诱导PC12细胞分化的影响[J]. 中药材, 2011, 34(4): 572-575 |
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| 作者姓名： | Lin LF Xiao F Lai YC Su JN Luo HM |
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| 作者单位： | 暨南大学医学院药理学系;暨南大学-香港大学脑功能与健康联合实验室; |
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| 基金项目： | 国家“211工程”建设经费资助 |
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| 摘 要： | 目的:探讨阿魏酸在低浓度碱性成纤维生长因子(bFGF)诱导大鼠肾上腺髓质嗜铬瘤细胞(PC12细胞)分化的作用及其初步机制。方法:在0 ng/mL或1 ng/mL bFGF条件下培养PC12细胞,以PC12细胞的突起长度及诱导率确定药效。结果:阿魏酸在无bFGF的情况下不能诱导PC12分化,但在低浓度bFGF(1 ng/mL)情况下,与bFGF(1 ng/mL)对照组比较可明显诱导PC12细胞分化(P<0.01),这种作用能被有丝分裂原激活的蛋白激酶(MAPK)特异性抑制剂PD98059所抑制。结论:阿魏酸可增强bFGF诱导PC12细胞分化,其机制可能与MAPK信号通路有关。
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| 关 键 词： | 阿魏酸 PC12细胞 突起生长 bFGF |
Effects of ferulic acid on bFGF-treated PC12 cells |
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| Lin Lian-feng,Xiao Fei,Lai Yong-chang,Su Ju-nian,Luo Huan-min. Effects of ferulic acid on bFGF-treated PC12 cells[J]. Journal of Chinese medicinal materials, 2011, 34(4): 572-575 |
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| Authors: | Lin Lian-feng Xiao Fei Lai Yong-chang Su Ju-nian Luo Huan-min |
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| Affiliation: | LIN Lian-feng1,XIAO Fei1,LAI Yong-chang1,SU Ju-nian1,LUO Huan-min1,2(1.Department of Pharmacology,Medical College,Jinan University,2.The Joint laboratory for Brain Function and Health,Jinan University-University of Hong Kong,Guangzhou 510632,China) |
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| Abstract: | Objective:To explore the effect and mechanism of ferulic acid on differentiation in bFGF-treated PC12 cells.Methods:The length of neurite outgrowth and the percentage of PC12 cells induced in the presence of 0 ng/mL or 1 ng/mL bFGF were assayed.Results:Compared with that of control group,ferulic acid could enhance the differentiation effect of bFGF(1 ng/mL) in PC12 cells(P<0.01) and the enhancing effect could be blocked by the specific MAPK kinase inhibitor,PD98059.Conclusion:Ferulic acid potentiates neurit... |
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| Keywords: | Ferulic acid PC12 cells Neurite outgrowth bFGF |
| 本文献已被 CNKI PubMed 等数据库收录！ |
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