| 附子双酯型生物碱的提取工艺研究 |
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| 作者姓名： | Liu Z Yan X Xu CX Hou DB Yuan XH |
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| 作者单位： | 西南科技大学生命科学与工程学院; |
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| 基金项目： | 四川省科技支撑项目(2008SZ0082) |
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| 摘 要： | 目的:探讨附子中3种双酯型生物碱提取的影响因素,确定适宜的提取条件。方法:采用HPLC法测定中乌头碱、乌头碱和次乌头碱的含量,采用单因素试验法,对附子双酯型生物碱的提取工艺进行研究。结果:最佳双酯型生物碱提取工艺为:在15℃条件下,将附子粗粉置于10倍无水乙醇中冷浸3次,每次1 d,双酯型生物碱收率为0.57%,质量分数为18.81%,其中中乌头碱、乌头碱和次乌头碱收率分别为0.16%、0.032%和0.38%。结论:该提取方法高效、低毒、经济、操作方便,适合工业化生产。
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| 关 键 词： | 附子 中乌头碱 乌头碱 次乌头碱 提取工艺 |
Extraction technology of diester-type alkaloids from Radix Aconiti lateralis |
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| Liu Z,Yan X,Xu CX,Hou DB,Yuan XH.Extraction technology of diester-type alkaloids from Radix Aconiti lateralis[J].Jorunal of Chinese Medicinal Materials,2011,34(11):1781-1784. |
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| Authors: | Liu Zhuo Yan Xing Xu Chun-Xia Hou Da-Bin Yuan Xiao-Hong |
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| Institution: | LIU Zhuo,YAN Xing,XU Chun-xia,HOU Da-bin,YUAN Xiao-hong(School of Life Science and Engineering,Southwest University of Science and Technology,Mianyang 621000,China) |
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| Abstract: | Objective:To determine the suitable extraction technology of diester-type alkaloids,such as mesaconitine,aconitine and hypaconitine from the roots of Aconitum carmichaeli(Radix Aconiti lateralis).Methods:The contents of mesaconitine,aconitine and hypaconitine were determined by HPLC.Single-factor experiment was used to study the extraction factors.Results:The suitable extraction technology for diester-type alkaloids was as follows:coarse sizings of Radix Aconiti lateralis was extracted by 10 times ethanol f... |
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| Keywords: | Aconitum carmichaeli Debx Mesaconitine Aconitine Hypaconitine Extraction technology |
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