新生儿缺氧缺血性脑病血清肌钙蛋白I的水平检测及其临床意义

目的研究新生儿缺氧缺血性脑病血清心肌肌钙蛋白I的水平变化与临床意义。方法50例HIE患儿（轻度14例，中度30例，重度6例），分别于住院第1天和第10天取静脉血和50例正常足月新生儿脐血用于检测cTnI水平。结果HIE患儿住院第1天时血清中cTnI含量明显高于对照组的脐血（P〈0．01）；轻度HIE组cTnI含量与对照组比较无显著性差异（P〉0．05）；中、重度HIE患儿与轻度患儿及对照组比较血清cTnI含量有显著性差异（P〈0．05）；HIE患儿越重，血清cTnI含量则越高；中、重度组HIE于住院治疗后10d时均比住院1d时显著下降（P〈0．05）。结论HIE组患儿血清cTnI明显高于对照组，说明HIE患儿存在心肌损伤，其对治疗和预后的判断有着重要的指导意义。

The Clinical Significance and Changes of Serum Cardiac Troponin I Levels in Newborns with Hypoxic-ischemic Encephalopathy

Objective To study the clinical significance and changes of serum cTnI levels in newborn with hypoxic-ischemic encephalopathy. Methods CTnI levels were detected in 50 newborns with HIE both on 1st day and on 10th day,and other 50 normal term newborns were detected as controls. Results CTnI levels in newborn with HIE on 1st day were obviously higher than those in controls. CTnI levels in newborns with mild HIE had no obvious difference with those in controls. CTnI levels in newborns with moderate and severe HIE were obviously higher than those in newborns with mild HIE and controls. With HIE deteriorating,cTnI levels increased. CTnI levels in newborn with moderate and severe HIE were obviously decreased after treatment. Conclusion. Serum cTnI levels in newborn with HIE were obviously higher than those in controls,it suggests newborns with HIE have myocardium injury. Detection of cTnI levels is important in diagnosis,therapy and prognosis.