Mossy fiber synapses on glutamate decarboxylase-immunoreactive neurons: evidence for feed-forward inhibition in the CA3 region of the hippocampus |
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| Authors: | M. Frotscher |
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| Affiliation: | (1) Institute of Anatomy, Johann Wolfgang Goethe University, Theodor-Stern-Kai 7, D-6000 Frankfurt am Main 70, Federal Republic of Germany |
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| Abstract: | Summary Mossy fibers are known to form excitatory synapses on pyramidal neurons in regio inferior of the hippocampus. This study demonstrates that the mossy fibers also establish synaptic contacts with glutamate decarboxylase-immunoreactive, supposedly GABAergic inhibitory neurons in the CA3 region. The observed connection provides a morphological basis for feed-forward inhibition of the pyramidal cells. |
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| Keywords: | Hippocampal mossy fibers GABAergicneurons GABAergic inhibition EM immunocytochemistry Rat |
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