| (9S)-红霉胺合成工艺的改进 |
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| 引用本文： | 刘明东,刘超,罗小勇,范举正. (9S)-红霉胺合成工艺的改进[J]. 华西药学杂志, 2008, 23(2): 168-169 |
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| 作者姓名： | 刘明东 刘超 罗小勇 范举正 |
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| 作者单位： | 四川大学华西药学院,四川成都,610041 |
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| 摘 要： | 目的改进地红霉素关键中间体(9S)-红霉胺的合成工艺。方法以红霉素为原料,经亲核加成、重氮化、氢化三步合成(9S)-红霉胺。结果优化工艺后,(9S)-红霉胺总收率为45.8%。结论改进后的方法成本低,操作简单,适合工业化生产。
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| 关 键 词： | 地红霉素 (9S)-红霉胺 合成 中间体 |
| 文章编号： | 1006-0103(2008)02-0168-02 |
| 修稿时间： | 2007-09-01 |
Improvement of synthetic technology of (9S)-erythromycylamine |
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| LIU Ming-dong,LIU Chao,LUO Xiao-yong,FAN Ju-zheng. Improvement of synthetic technology of (9S)-erythromycylamine[J]. West China Journal of Pharmaceutical Sciences, 2008, 23(2): 168-169 |
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| Authors: | LIU Ming-dong LIU Chao LUO Xiao-yong FAN Ju-zheng |
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| Abstract: | OBJECTIVE To improve synthetic technology of(9S)-Erythromycylamine.METHODS(9S)-Erythromycylamine was synthesized from Erythromycin through nucleophilic addtion,diazotization and hydrogenation reactions.RESULTSThe total yield of(9S)-Erythromycylamine was 45.8%.CONCLUSIONThis method is convenient and available for industrial production. |
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| Keywords: | Dirithromycin (9S)-Erythromycylamine Synthesis Intermediate |
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