反复呼吸道感染患儿血清免疫球蛋白、IgG亚类及细胞免疫水平分析

目的探讨d,JD反复呼吸道感染（RRTI）的发病机制。方法选择我科被诊断为反复呼吸道感染的患儿35例．另选正常35例儿童为对照组，检测血清IgG、IgA、IgM及IgG亚类水平；检测CD分子的表达。结果RRTI组患儿的血清IgG、IgA水平与对照组比较差异无统计学意义，IgM水平低于对照组，RRTI组患儿的血清IgG2和IgG4水平均低于对照组，IgG1、IgG3水平差异无显著性。35例RRTI患儿中IgG亚类缺陷共17例，检出率为48．6％（17／35）。RRTI组患儿的CD3、CD4分子表达水平较对照组明显降低，CD8、CD4／CD8、CD19、CD16＋56等表达两组比较无差异。结论IgG亚类能够比较敏感地反映反复呼吸道感染患儿的体液免疫功能，IgG亚类缺陷的患儿多伴有不同程度的T细胞功能障碍．因此在临床工作中应注意监测患儿血清IgG亚类及各项细胞免疫功能。

Analysis of serum immunoglobulin, IgG subclass and cell immunity of children with repeated respiratory tract infection

Objective To discuss the pathogenesis of children with repeated respiratory tract infection. Methods Selected 35 children with repeated respiratory tract infection ,another 35 normal children in control group .Detected serum IgG, I- gA in them, IgM and IgG subclass levels and expression of CD molecules. Results There was no significant difference between RRTI group and control group with serum IgG and IgA level, but the level of IgM in RRTI group was lower than that of control group, the serum IgG2 and IgG4 was lower than the control group, there was no difference between RRTI group and control group with IgGl,IgG3. 17 cases in RRTI group with IgG subclass deficiencies, the detection rate was 48.6%（17/35）.The level of CD3 ,CD4 expression was lower than the control group. There were no difference between the two groups with CD8 ,CD4/ CD8,CD19,CD16＋56 expression. Conclusion IgG subclasses can reflect repeated respiratory tract infection children＇s humoral immune function, IgG subclass deficiencies is often accompanied by T cell dysfunction ,therefore, monitoring of serum IgG subclass function and the cellular immune function should be done.