胸腺肽α1治疗老年慢性阻塞性肺病急性发作期的疗效观察 |
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引用本文: | 陈海英,张键.胸腺肽α1治疗老年慢性阻塞性肺病急性发作期的疗效观察[J].中国航天工业医药,2012(6):14-16. |
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作者姓名: | 陈海英 张键 |
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作者单位: | 湖南省常德市第一人民医院老年病科,415000 |
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摘 要: | 目的探讨胸腺肽α1治疗老年慢性阻塞性肺病(COPD)急性发作期的疗效。方法将54例老年COPD急性期住院患者随机分为常规治疗组和胸腺肽治疗组2组,胸腺肽治疗组在常规治疗组基础上加用胸腺肽α1 1.6mg皮下注射.1次/d,疗程2周。观察2组患者血清C反应蛋白(CRP)和降钙素原(PCT)水平、细胞免疫功能水平和临床疗效。结果治疗后胸腺肽组CD3+、CD4+,CD4+/CD8+水平较常规组明显改善(P〈0.05),CRP和PCT水平较常规组明显下降(P〈0.05),临床有效率较常规组明显提高(P〈0.05)。结论胸腺肽d1能改善老年COPD患者的免疫功能,联合胸腺肽仪1治疗老年COPD急性发作期效果明显。
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关 键 词: | 胸腺肽α1 慢性阻塞性肺病老年 |
The curative effect of the thymosin alpha 1 in elderly chronic obstructive pulmonary disease during acute period |
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Authors: | Chen Haiying Zhang Jian |
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Institution: | . The First People' s Hospital of Changde, Changde 415000 |
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Abstract: | Objective To study the curative effect of the thymosin alpha 1 in elderly chronic obstructive pulmonary dis- ease (COPD) during acute period. Methods 54 elderly inpatients with COPD during acute period were divided into two groups randomly: conventional therapy group and thymosin alpha 1 therapy group. Both two groups were treated with routine method, but the patients of the thymosin alpha 1 therapy group received 1.6mg thymosin alpha 1 through subcutaneous injection qd for 2 weeks, to observe serum C-reactive protein (CRP) and procaleitonin (PCT),cellular immune function and therapeutic effect. Results CD3+,CD4+,CD4+/CD8+ of the thymosin alpha 1 therapy group were improved significantly and better than conventional therapy group (P〈0.05) ,CRP and PCT were obviously decreased (P〈0.05), the clinical effective rate was higher (P〈0.05). Conclusion Thymosin alpha 1 is of great benefit to immune function of elderly COPD patients. The therapeutic effect of combination with thymosin alpha 1 therapy in elderly COPD patients during acute period is obvious. |
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Keywords: | Thymosin alpha 1 Chronic obstructive pulmonary disease Elderly |
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