| 热熔挤出技术制备吡罗昔康固体分散体 |
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| 引用本文： | 张庆刚,赵星星.热熔挤出技术制备吡罗昔康固体分散体[J].齐鲁药事,2013(9):526-527,556. |
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| 作者姓名： | 张庆刚 赵星星 |
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| 作者单位： | 山东新时代药业有限公司,山东临沂273400 |
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| 摘 要： | 目的采用热熔挤出技术制备难溶性药物吡罗昔康固体分散体,来提高其溶出速率。方法以共聚维酮(PVP-VA64)为亲水性载体材料,聚乙二醇6000为增塑剂,采用热熔挤出技术制备吡罗昔康固体分散体。通过比较差示扫描量热图谱和累积溶出曲线,来表征和评价所制备的固体分散体。结果所制备的固体分散体溶出速率较物理混合物均显著提高。结论热熔挤出技术适用于制备吡罗昔康固体分散体,药物是以无定型分散在载体中,溶出度得到显著提高。
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| 关 键 词： | 热熔挤出 差示扫描量热法 溶出度 吡罗昔康 固体分散体 |
Preparation of Piroxicam Solid Dispersion by hot-melt extrusion technology |
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| ZHANG Qing-gang,ZHAO Xing-xing.Preparation of Piroxicam Solid Dispersion by hot-melt extrusion technology[J].qilu pharmaceutical affairs,2013(9):526-527,556. |
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| Authors: | ZHANG Qing-gang ZHAO Xing-xing |
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| Institution: | ( Shandong Newtime Pharmaceutical Co. , Ltd. , Linyi 273400, China ) |
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| Abstract: | Objective To improve the dissolution rate of piroxicam by preparing piroxicam solid dispersion with hot - meh extrusion （HME） technology. Methods Using PVP - VA64 as hydrophilic carrier and PEG6000 as phthalate, piroxi- cam solid dispersion was prepared by hot - melt extrusion and characterized by DSC and drug dissolution. Results The dis- solution rate of piroxicam solid dispersion is much faster than its physical mixture. Conclusion Hot - melt extrusion tech- nology was suitable for preparing piroxicam solid dispersion, which can significantly increase drug dissolution. |
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| Keywords: | Hot - melt extrusion DSC Dissolution piroxicam Solid dispersion |
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