贞芪扶正胶囊对大鼠实验性肝癌发生发展的影响

目的 :观察贞芪扶正胶囊在化学致癌剂二乙基亚硝胺 (diethylnitrosamine ,DENA)诱发大鼠肝癌过程中 ,对肝癌发生、发展的影响。方法 :实验分为 4组 ,除单纯致癌组 (D组 )外 ,其余各组大鼠均在给予致癌剂前 (A组 )、同时 (B组 )或后 (C组 )加给贞芪扶正胶囊。在给予致癌剂 2 0周后取肝脏作肉眼、光镜和电镜检查。结果 :单纯致癌组大鼠均形成肝癌。服用贞芪扶正胶囊的各组情况则有较大差异 ,A组大鼠显示致癌剂对肝脏毒性损伤明显低于其他各组 ,并且当其他各组动物均已形成肝癌甚至已有转移时 ,此组中仅有少数大鼠形成肿瘤 ,多数大鼠则仅出现DENA毒性刺激而形成的细胞增生结节。结论 :贞芪扶正胶囊有预防或延缓肝癌发生的作用

Influence of A-L Tonic Capsule on Experimental Hepatocarclnogenesls and Development in Rats

Objective To observe the influence of A L tonic capsule on experimental hepatocarcinogenesis and development induced by diethylnitrosamine(DENA) in rats.Methods The experimental rats were divided into 4 groups.Exception of D group in which the rats were only administered with DENA,the rats in A,B,C group were administered with DENA and A L tonic capsule(A group,the rats were previously fed with A L tonic capsule for 8 weeks and then added DENA;B group,DENA and A L tonic capsule were simultaneously administered;C group,the rats were administered by DENA for 7 weeks and then added A L tonic capsule).The liver of all rats was examined using gross,light and electron microscopic methods after 20 weeks administered with DENA. Results All rats in D group formed hepatocellular carcinoma.There was difference in tumor formation between A,B and C group ,liver tissue toxic injury induced by carcinogen in A group was mild than that in other experimental groups,a few rats in A group formed hepatocellular carcinoma and most of them only showed cell proliferation nodules in liver due to stimulated by DENA when all rats in other experimental groups formed hepatocellular carcinoma and even metastasis happened.Conclusion A L tonic capsule could effectively prevent or postpone hepatocarcinogenesis in rats.