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Simvastatin does not prevent acute cardiac allograft rejection in CD28-deficient mice |
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| Authors: | René Schramm Rudolph Schmits Hans-Joachim Sch?fers Michael D Menger |
| Institution: | (1) Department of Thoracic and Cardiovascular Surgery, University of Saarland, Kirrbergerstr., 66421 Homburg, Saarland, Germany;(2) Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg, Saarland, Germany |
| Abstract: | BackgroundHeterotopic cardiac transplantation in mice was used to determine whether complementary immunomodulation by statins prevents lymphocyte function-associated antigen (LFA)-1-dependent acute allograft rejection in vivo. |
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