The influence of steroid therapy and recombinant human erythropoietin on the growth of children with renal disease |
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| Authors: | Lesley Rees Susan P. A. Rigden Cyril Chantler |
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| Affiliation: | (1) Department of Paediatrics, United Medical and Dental Schools of Guy's and St Thomas's Hospitals, Guy's Hospital, St Thomas's Street, SE1 9RT London, UK;(2) Royal Free Hospital, Pond Street, Hampstead, NW3 London, UK |
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| Abstract: | Long-term steroid therapy has a depressant effect on hypothalamo-pituitary pulsatile secretion of growth hormone (GH), and this results in an attenuated pubertal growth spurt. Oxandrolone and recombinant human GH improve growth rates in children taking long-term steroid therapy for renal disease, but there are potential side effects. Treatment with recombinant human erythropoietin improved the growth of three prepubertal, but not three pubertal haemodialysis patients. |
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| Keywords: | Steroids Growth Growth hormone Oxandrolone Steroid-sensitive nephrotic syndrome Renal transplant Erythropoietin |
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