The use of intermediate-purity clotting factor concentrates and HIV disease progression in men with haemophilia |
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Authors: | C. A. SABIN J. PASI A. N. PHILLIPS P. LILLEY J. ELFORD C. A. LEE |
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Affiliation: | Haemophilia Centre and Haemostasis Unit, Department of Haematology;HIV Research Unit, Department of Primary Care and Population Sciences, Royal Free Hospital and School of Medicine, Rowland Hill Street, London NW3 2PF |
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Abstract: | Summary. On the basis of evidence from the immune systems of patients with haemophilia infected with HIV, patients in the UK have been switched to high-purity clotting factor concentrates. However, there is very little information currently available on the effect of intermediate-purity clotting factor concentrates on progression of HIV disease. Among 99 HIV-positive men with severe factor VIII deficiency registered at The Royal Free Hospital Haemophilia Centre, a 100 IU kg-1 increase in the yearly amount of concentrate received did not appear to be associated with more rapid progression to AIDS, death or to a low CD4 count. However, the use of total concentrate usage may mask a more subtle effect of specific concentrate contaminants on the progression of HIV disease. |
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Keywords: | AIDS clotting factor concentrate haemophilia HIV |
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