| 深海鱼油毒理学安全性评价 |
| |
| 引用本文： | 曾强,张静姝,刘忠慧,刘洪亮. 深海鱼油毒理学安全性评价[J]. 职业与健康, 2012, 28(13): 1569-1571 |
| |
| 作者姓名： | 曾强 张静姝 刘忠慧 刘洪亮 |
| |
| 作者单位： | 天津市疾病预防控制中心环境与健康所,300011 |
| |
| 摘 要： | 目的对深海鱼油进行毒理学安全性评价,为其食用安全性提供科学依据。方法采用急性经口毒性试验,遗传毒性试验和30 d喂养试验进行检测评价。结果深海鱼油对两种性别的大、小鼠经口急性毒性最大耐受量(MTD)均大于15.0 g/kg;Ames试验、小鼠骨髓细胞微核试验和小鼠睾丸染色体畸变试验结果均为阴性;30 d喂养试验也未见明显的毒性作用。结论深海鱼油为无毒级,无遗传毒性,是一种安全的保健食品。
|
| 关 键 词： | 深海鱼油 毒理学评价 保健食品 |
Toxicological safety assessment of deep-sea fish oil |
| |
| ZENH Qiang , ZHANG Jing-shu , LIU Zhong-hui , LIU Hong-liang. Toxicological safety assessment of deep-sea fish oil[J]. Occupation and Health, 2012, 28(13): 1569-1571 |
| |
| Authors: | ZENH Qiang ZHANG Jing-shu LIU Zhong-hui LIU Hong-liang |
| |
| Affiliation: | Department for Environment and Health,Tianjin Centers for Disease Control and Prevention,Tianjin,300011,China |
| |
| Abstract: | [Objective]To assess the toxicological safety of deep-sea fish oil.[Methods]The toxicity was determined by transoral acute toxicity,genetic toxicity tests,and 30-day feeding experiment.[Results] The maximum tolerated dose(MTD) of deep-sea fish oil on male and female rats and mice were all larger than 15.0 g/kg.BW.The results of Ames test,mouse bone marrow micronucleus test and detection of chromosome aberration experiment were negative.No significant toxicity was observed by 30-day feeding experiment.[Conclusion]Deep-sea fish oil is a safe health food without toxicity and genetic toxicity. |
| |
| Keywords: | Deep-sea fish oil Toxicological assessment Health food |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
