青岛地区1206例孕妇羊水染色体核型分析

目的评价羊水细胞的染色体核型分析对妊娠中期的高危孕妇进行产前诊断的意义。方法对妊娠19～23周的高危孕妇进行羊膜腔穿刺术并进行细胞培养染色体核型分析。结果羊水细胞培养成功率99.9%,检出染色体异常47例,包括21-三体23例,18-三体2例,性染色体异常5例,22-三体1例以及其他染色体结构异常16例。结论孕妇羊水细胞染色体核型检查,能安全有效的对胎儿染色体异常进行产前诊断,对于减少具有染色体病患儿的出生具有重要的指导意义。

chromosome karyotype analysis of pregnant amniotic fluid in Qingdao area 1206 cases

Objective:Evaluation of amniotic fluid cells karyotype analysis on second trimester of pregnant women at risk for prenatal diagnosis.Method: From 19 to 23 weeks of pregnancy in pregnant women at risk of amniocentesis and cell culture karyotype analysis.Result:Amniotic fluid cell culture success rate of 99.9%,detection of chromosome abnormalities in 47 cases,including 23 cases of trisomy 21,18-trisomy 2 cases,5 cases with sex chromosome abnormalities,trisomy 22 in 1 cases and other structural chromosomal abnormality in 16 cases.Conclusion:Pregnant amniotic fluid cell karyotype,can be safe and effective for fetal chromosome abnormalities for prenatal diagnosis,chromosome disease patients to reduce the birth has an important guiding significance.