| 危重哮喘患者血BNP、cTnI、NO的变化及与心功能关系 |
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| 引用本文： | 王伟,王晓静,赵洪,黄鹤,舒冬冬.危重哮喘患者血BNP、cTnI、NO的变化及与心功能关系[J].临床肺科杂志,2011,16(9):1337-1338. |
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| 作者姓名： | 王伟 王晓静 赵洪 黄鹤 舒冬冬 |
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| 作者单位： | 合肥,解放军105医院呼吸内科,安徽,230031 |
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| 摘 要： | 目的探讨危重支气管哮喘并充血性心力衰竭（CHF）患者血清脑钠素（BNP）、心肌肌钙蛋白I（cTnI）、一氧化氮（NO）的变化及其与心功能关系。方法选择住院的危重支气管哮喘患者60例,其中合并CHF组26例,无CHF组34例。治疗前后,分别采用ELISA、RIA、Griess法测定血清BNP、cTnI、NO含量;彩色多普勒超声心动图（CDE）测定左室射血分数（LVEF）;SPSS 13.0软件分析数据。结果危重支气管哮喘并CHF患者血清BNP、cTnI、NO含量显著升高,LVEF水平降低,两组比较有显著性差异（P〈0.01）;且BNP、cTnI、NO水平与LVEF呈直线负相关。治疗后血清BNP、cTnI、NO含量明显降低（P〈0.01）。结论 BNP、cTnI、NO等神经内分泌介质可能参与了危重哮喘患者心衰的发生与发展过程,早期的心肌保护有助于心衰的防治。
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| 关 键 词： | 支气管哮喘 危重 脑钠素 心肌肌钙蛋白I 一氧化氮 心功能 |
The relationship between the changes of serum BNP,cTnI and NO in patients with severe bronchial asthma and heart function |
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| WANG Wei,WANG Xiao Jing,ZHAO Hong,HUANG He,SHU Dong-dong.The relationship between the changes of serum BNP,cTnI and NO in patients with severe bronchial asthma and heart function[J].Journal of Clinical Pulmonary Medicine,2011,16(9):1337-1338. |
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| Authors: | WANG Wei WANG Xiao Jing ZHAO Hong HUANG He SHU Dong-dong |
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| Affiliation: | WANG Wei,WANG Xiao Jing,ZHAO Hong,HUANG He,SHU Dong-dong.Department of Respiratory Medicine,The 105th Hospital of PLA,Hefei,Anhui 230031,China |
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| Abstract: | Objective To investigate the changes of serum brain natriuretic peptide(BNP),cardiac troponin I(cTnI) and nitric oxid(NO) in patients with severe bronchial asthma with congestive heart failure(CHF) and the relationship with heart function.Methods Sixthty patients of severe bronchial asthma,twenty-six patients with CHF and thirty-four without,were selected.Before and after the treatment,the concentrations of serum BNP,cTnI and NO were measured by the ways of ELISA,RIA and Griess.Left ventricular rejection fr... |
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| Keywords: | bronchial asthma severe brain natriuretic peptide cardiac troponin I nitric oxid heart function |
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