Multiple contrast type tests for the evaluation of animal carcinogenicity studies |
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| Authors: | Mohammad Rahman Ram Tiwari |
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| Institution: | 1. Division of Biometrics-6, Office of Biostatistics, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA;2. Intermediate Office, Office of Biostatistics, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA |
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| Abstract: | The Cochran–Armitage (CA) test is frequently used for testing the dose–response relationship in tumor incidence. This test is based on a weighted linear regression of proportions. It is well known that the CA test lacks power for nonlinear tumor outcomes. For general shape of outcomes, Hothorn and Bretz (2000) proposed a multiple contrast (MC) test. This test suggests the use of the maximum over several single contrasts, where each of them is chosen appropriately to cover a specific dose–response shape. In this work, two new test procedures are proposed and they are compared to the CA and MC tests using power. |
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| Keywords: | Animal carcinogenicity study Cochran–Armitage test dose–response relationship multiple contrast test |
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