| 感速康胶囊质量控制方法研究 |
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| 引用本文： | 刘鹏翰,韦庚龙,潘声遣,陆来祥,黄志长. 感速康胶囊质量控制方法研究[J]. 中国药业, 2007, 16(2): 38-39 |
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| 作者姓名： | 刘鹏翰 韦庚龙 潘声遣 陆来祥 黄志长 |
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| 作者单位： | 广西天天乐药业有限公司,广西,柳州,545100 |
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| 摘 要： | 目的建立感速康胶囊的质量控制方法。方法用薄层色谱法对感速康胶囊中的金银花、大青叶进行定性鉴别，用高效液相色谱法测定样品中绿原酸的含量。高效液相色谱条件为Vp-ODSC18柱（150mm×4．6mm，5μm），流动相为乙腈-0．1％磷酸（10：90），流速为1mL／min，检测波长为327nm，柱温为30℃。结果薄层色谱鉴别斑点清晰；绿原酸质量浓度在5～50μg／mL范围内与峰面积线性关系良好，r=0．9998，平均回收率为99．96％，RSD为1．27％。结论该方法可用于感速康胶囊的质量控制。
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| 关 键 词： | 感速康胶囊 金银花 大青叶 绿原酸 薄层色谱法 高效液相色谱法 |
| 文章编号： | 0006-4931（2007）02-0038-02 |
| 收稿时间： | 2006-05-12 |
| 修稿时间： | 2006-07-18 |
Study on Quality Control of Gansukang Capsule |
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| Liu Penghan,Wei Genglong,Pan Shengqian,Lu Laixiang,Huang Zhichang. Study on Quality Control of Gansukang Capsule[J]. China Pharmaceuticals, 2007, 16(2): 38-39 |
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| Authors: | Liu Penghan Wei Genglong Pan Shengqian Lu Laixiang Huang Zhichang |
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| Affiliation: | Liu Penghan, Wei Genglong, Pan Shengqian, Lu Laixiang, Huang Zhichang ( Guangxi Tiantianle Pharmaceutical Co., Ltd., Liuzhou, Guangxi, China 545100) |
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| Abstract: | Objective To establish a method for the quality control of Gansukang capsule. Methods The Lonicera japonica Thunb. and lsatis indigotica Fort. in this medicine were identified by TLC. The chlorogenic acid was determined by HPLC systerm consisted of Vp- ODS C18 column （150 mm ×4.6 mm, 5 μm）,acetontrile-0. 1% phosphoric acid （10：90） mixtures as mobile phase, detection wavelength at 327 nm, flow rate of 1.0 mL/min, column temperature was 30℃. Results The TLC spots were clear and the calibration curve of chlorogenic acid was linear within the range of 5-50μg/mL （r =0. 999 8）, the average recovery rate was 99.96%, RSD was 1.27%. Conclusion The method can be used for the quanlity control of Gransukang capsule. |
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| Keywords: | Gansukang capsule Lonicera japonica Thunb. Isatis indigotica Fort. chlorogenic acid TLC HPLC |
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