| An open add-on study on cyclophosphamide in patients with refractory myasthenic crisis |
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| 作者姓名： | 蒋建明 涂来慧 吴涛 张仁琴 丁素菊 蔡建英 |
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| 作者单位： | Department of Neurology，Changhai Hospital，Second Military Medical University，Department of Neurology，Changhai Hospital，Second Military Medical University，Department of Neurology，Changhai Hospital，Second Military Medical University，Department of Neurology，Changhai Hospital，Second Military Medical University，Department of Neurology，Changhai Hospital，Second Military Medical University，Department of Neurology，Changhai Hospital，Second Military Medical University，Shanghai 200433，China Shanghai 200433，China，Shanghai 200433，China，Shanghai 200433，China，Shanghai 200433，China，Shanghai 200433，China |
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| 摘 要： | Objective: To assess the efficacy and side effects of cyclophosphamide on refractory myasthenic crisis. Methods: Five patients of myasthenic crisis refractory to usual comprehensive treatment, entered an open additional study with cyclophosphamide 200 mg VD q. d or 400 mg VD q. o. d with 6-10 g of total dosage. The patients were followed up for 1-8 years. Results: All the 5 patients were effectively treated with obvious remission in 3 and improvement in 2. Two patients have returned to partial work. The side effects were tolerable. Conclusion: The present clinical trial showed that cyclophosphamide was effective, particularly in a long term as an additional therapy for treating MG patients with refractory crisis of myasthenia gravis.
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An open add-on study on cyclophosphamide in patients with refractory myasthenic crisis |
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| JIANG Jian-ming TU Lai-hui,WU Tao,ZHANG Ren-qin,DING Su-ju
CAI Jian-ying.An open add-on study on cyclophosphamide in patients with refractory myasthenic crisis[J].Journal of Medical Colleges of PLA(China),2003,18(1). |
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| Authors: | JIANG Jian-ming TU Lai-hui WU Tao ZHANG Ren-qin DING Su-ju
CAI Jian-ying |
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| Institution: | JIANG Jian-ming TU Lai-hui,WU Tao,ZHANG Ren-qin,DING Su-ju
CAI Jian-ying Department of Neurology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China |
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| Abstract: | Objective: To assess the efficacy and side effects of cyclophosphamide on refractory myasthenic crisis. Methods: Five patients of myasthenic crisis refractory to usual comprehensive treatment, entered an open additional study with cyclophosphamide 200 mg VD q. d or 400 mg VD q. o. d with 6-10 g of total dosage. The patients were followed up for 1-8 years. Results: All the 5 patients were effectively treated with obvious remission in 3 and improvement in 2. Two patients have returned to partial work. The side effects were tolerable. Conclusion: The present clinical trial showed that cyclophosphamide was effective, particularly in a long term as an additional therapy for treating MG patients with refractory crisis of myasthenia gravis. |
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| Keywords: | myasthenia gravis crisis cyclophosphamide therapy |
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