Pneumolysin, PspA, and PspC contribute to pneumococcal evasion of early innate immune responses during bacteremia in mice |
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| Authors: | Quin Lisa R Moore Quincy C McDaniel Larry S |
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| Affiliation: | Department of Microbiology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA. |
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| Abstract: | The pneumococcal virulence factors include capsule, PspA, PspC, and Ply. Cytometric analysis demonstrated that the greatest levels of C3 deposition were on a Deltaply PspA(-) PspC(-) mutant. Also, Ply, PspA, and PspC expression resulted in C3 degradation in vitro and in vivo. Finally, blood clearance assays demonstrated that there was enhanced clearance of Deltaply PspA(-) PspC(-) pneumococci compared to the clearance of nonencapsulated pneumococci. |
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