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| PTSD大鼠杏仁核神经元和突触的超微结构研究 | |
| 引用本文： | 刘冬娟,韩芳,刘宁宇,石玉秀. PTSD大鼠杏仁核神经元和突触的超微结构研究[J]. 解剖科学进展, 2009, 15(1): 17-20 |
| 作者姓名： | 刘冬娟 韩芳 刘宁宇 石玉秀 |
| 作者单位： | 1. 中国医科大学电子显微学研究室,辽宁,沈阳,110001 2. 中国医科大学组织胚胎学教研室,辽宁,沈阳,110001 3. 中国医科大学电子显微学研究室,辽宁,沈阳,110001;中国医科大学组织胚胎学教研室,辽宁,沈阳,110001 |
| 基金项目： | 国家自然科学基金，辽宁省教育厅科技攻关项目 |
| 摘 要： | 目的研究创伤后应激障碍(PTSD)大鼠杏仁核神经元及突触的超微结构改变。方法采用大鼠PTSD-无连续单一应激(SPS)模型,于SPS刺激后1d、7d、14d取大脑杏仁核组织,制备成超薄切片,进行透射电镜观察。结果模型组杏仁核可见凋亡神经元,尤以SPS-7d为明显,神经元胞质内线粒体外膜局部破损、嵴减少或空泡化,粗面内质网和高尔基复合体呈不同程度扩张,突触结构也有异常。结论PTSD时杏仁核神经元发生凋亡和突触变性改变。 |
| 关 键 词： | 创伤后应激障碍 杏仁核 神经元 突触 超微结构 |
Apoptosis and Synaptic Ultrastructure of Amygdala Neurons in Rats of Posttraumatic Stress Disorder |
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| LIU Dong-juan,HAN Fang,LIU Ning-yu,SHI Yu-xiu. Apoptosis and Synaptic Ultrastructure of Amygdala Neurons in Rats of Posttraumatic Stress Disorder[J]. Progress of Anatomical Sciences, 2009, 15(1): 17-20 | |
| Authors: | LIU Dong-juan HAN Fang LIU Ning-yu SHI Yu-xiu |
| Affiliation: | Department of Histology and Embryology;China Medical University;Liaoning Shenyang 110001 China |
| Abstract: | Objective To observe the ultrastructure change of amygdala neuron and synapse in rats of posttraumatic stress disorder(PTSD).Method Establishment of single-prolonged stress(SPS)of PTSD rat,materials of amygdala were gained at 1d,7d and 14d after SPS exposure,ultrathin sections were made and the tissues were observed with transmission electron microscope.Results Apoptosis of amygdala neurons was seen in the model,and obviously at 7d after SPS exposure,with rupture of mitochondria external membrane,decreased ... |
| Keywords: | Posttraumatic stress disorder amygdala neuron synapse ultrastructure |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |