心可舒对冠心病合并2型糖尿病患者 NO、ET的影响

目的 观察心可舒胶囊对冠心病合并2犁糖尿病患者血浆一氧化氮(NO)、内皮素(ET)水平的影响, 探讨心可舒胶囊的治疗作用.方法 符合入选标准的80例患者随机分为两组,每组各40例.治疗3个月后,比较患 者血浆NO、ET水平的变化.结果 治疗组NO明显升高,且高于对照组(P<0.01);ET明显降低,且低于对照组(P<0.01).结论 心可舒胶囊可能通过升高NO、降低ET发挥保护血管内皮作用.

Influence of Xin-ke-shu Capsule on NO and ET in Patients with Coronary Artery Disease and Type 2 Diabetes Mellitus

Objective To observe the influence of Xin-ke-shu Capsule (XKSC) on NO and ET in patients with coronary artery disease(CAD) combined with type 2 diabetes mellitus(T2DM), and to investigate its mechanism of treatment. Methods 80 patients with CAD combined with T2DM were randomly recruited into two groups: 40 patients in the treatment group were treated by conventional therapy plus XKSC, and the 40 in the control group treated by conventional therapy exclusively. The plasma level of NO and ET was observed before and after the three-month therapeutic course. Results The plasma level of ET in the treatment group significantly decreased after the treatmaent and was lower than that in the control group(P<0.01), but NO in the treatment group elevated significantly and was higher than that in the control group (P<0.01). Conclusion Xin-ke-shu Capsule displays its effect on protecting vascular endothelia by elevating the level of NO and decreasing the plasma level of ET.