沙丁胺醇联合布地奈德雾化吸入治疗支气管哮喘急性发作的临床效果

目的探讨沙丁胺醇联合布地奈德雾化吸入治疗支气管哮喘急性发作的临床效果。方法将我院2017年1月至2018年12月收治的80例支气管哮喘急性发作患者按随机数字表法分为对照组(n=40)和观察组(n=40)。对照组给予沙丁胺醇雾化吸入治疗,观察组给予沙丁胺醇联合布地奈德雾化吸入治疗。比较两组的治疗效果。结果观察组咳嗽、哮鸣音、气促缓解时间均短于对照组(P<0.05)。治疗后,两组患者的FVC、FEV1、PEF均升高,且观察组高于对照组(P<0.05)。治疗后,两组患者IL-5水平均降低、IL-10水平均升高,且观察组优于对照组(P<0.05)。治疗后,两组患者HMGB1、IgE水平及嗜酸性粒细胞计数较治疗前显著降低,且观察组低于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论沙丁胺醇联合布地奈德雾化吸入治疗支气管哮喘急性发作的效果理想,其可改善患者的肺功能,减轻气道高炎症反应,不良反应轻,值得临床推广应用。

Clinical effect of atomization inhalation of salbutamol combined with budesonide in the treatment of acute attack of bronchial asthma

Objective To investigate the clinical effect of atomization inhalation of salbutamol combined with budesonide in the treatment of acute attack of bronchial asthma. Methods From January 2017 to December 2018, 80 patients with acute attack of bronchial asthma enrolled in our hospital were divided into control group(n=40) and observation group(n=40) according to the method of random number table. The control group was given salbutamol atomization inhalation treatment, the observation group was given atomization inhalation treatment of salbutamol combined with budesonide. The therapeutic effects of the two groups were compared. Results The remission time of cough, wheezing and shortness of breath in the observation group were shorter than those in the control group(P<0.05). After treatment, the FVC, FEV1 and PEF of the two groups increased, and those of the observation group were higher than the control group(P<0.05). After treatment,the level of IL-5 decreased, the level of IL-10 increased in both groups, and those in the observation group were better than the control group(P<0.05). After treatment, the levels of HMGB1, IgE and eosinophil count in the two groups were significantly lower than those before treatment, and those in the observation group were lower than the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05). Conclusion Atomization inhalation of salbutamol combined with budesonide has a rational effect in the treatment of acute attack of bronchial asthma, it can improve the lung function of patients, reduce the airway hyperinflammatory reaction with mild adverse reactions, which is worthy of clinical promotion and application.