Efect of periodontal disease and non surgical periodontal treatment on
C-reactive protein. Evaluation of type 1 diabetic patients |
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Authors: | Fernando Llambés Francisco J. Silvestre Antonio Hernández-Mijares Rami Guiha Daniel Bautista Raúl Caffesse |
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Affiliation: | 1. DDS, PhD. University of Valencia (Spain);2.DDS, MD, PhD. Department of Stomatology. Dr. Peset Hospital Valencia (Spain);3.MD, PhD. Department of Endocrinology Dr. Peset Hospital, Valencia (Spain);4.DDS, MS, PhD. Misr International University, Cairo, (Egypt);5.MD, PhD. Department of Epidemiology. Dr. Peset Hospital, Valencia (Spain);6.DDS, MS, PhD. Department of Periodontics. Complutense University, Madrid (Spain) |
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Abstract: | Objectives: The purpose of this study was to analyze how anti-infectious periodontal treatment affects C reactive protein (CRP) values in patients with type 1 diabetes, and correlate baseline CRP levels with periodontal disease severity. Study Design: A cohort of fifty three subjects with type 1 diabetes and moderate to severe periodontitis were recruited. Periodontal parameters were measured, and blood samples were obtained to evaluate high-sensitivity C-reactive protein (hs-CRP). Group 1 was treated with scaling, root planning, and systemic administration of doxycycline. Group 2 received only scaling and root planning.Results: Hs-CRP was reduced after periodontal treatment in group 1 (-0.22 mg/l) and 2 (-0.21 mg/l ) but this reduction was not statistically significant, even in the patients with the best response to periodontal treatment. However, significant correlation appeared between hs-CRP and mean probing pocket depth (PPD) (p=0, 01) and mean clinical attachment level (CAL) (p=0,03). Conclusions: Non-surgical periodontal treatment couldn’t reduce hs-CRP values, however, it was found an association between advanced periodontitis and elevated blood hs-CRP levels in patients with type 1 diabetes. It can be speculated that periodontal disease increases production of pro-inflammatory mediators in patients with type 1 diabetes, but other producing sources of these pro-inflammatory substances may exist. Key words:Periodontal disease, periodontitis, diabetes mellitus type 1, periodontal therapy, C reactive protein. |
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