双环醇联合多烯磷脂酰胆碱治疗甲亢性肝损伤的疗效观察

目的研究双环醇联合多烯磷脂酰胆碱治疗甲状腺功能亢进症(甲亢)性肝损伤的疗效。方法87例甲亢性肝损伤患者,依据治疗方式不同分为联合组(45例)与单一组(42例)。联合组患者采取双环醇联合多烯磷脂酰胆碱方案治疗,单一组患者采取单独使用多烯磷脂酰胆碱方案治疗。比较两组血清指标超氧化物歧化酶(SOD)、甲状腺球蛋白抗体(TGA)、甲状腺微粒体抗体(TMA)、血清甲状腺球蛋白(HTG)、总胆红素(TBIL)、谷氨酸转氨酶(ALT)、天门冬氨酸氨基转移酶(AST)、谷氨酰转肽酶(GGT)]水平及治疗效果。结果治疗后,联合组的SOD为(246.93±90.03)ng/ml,高于单一组的(209.04±76.16)ng/ml,TGA、TMA、HTG分别为(19.56±11.03)%、(20.01±13.88)%、(8.25±7.09)ng/ml,均低于单一组的(24.21±9.16)%、(26.35±14.03)%、(14.95±8.74)ng/ml,差异均有统计学意义(P<0.05)。治疗后,联合组的ALT、AST、GGT、TBIL分别为(48.6±11.5)U/L、(52.4±8.8)U/L、(61.3±16.2)U/L、(22.4±9.8)mmol/L,均低于单一组的(55.8±11.3)U/L、(56.9±9.8)U/L、(78.2±11.5)U/L、(30.4±12.5)mmol/L,差异均有统计学意义(P<0.05)。联合组的治疗总有效率为91.11%,高于单一组的61.90%,差异有统计学意义(P<0.05)。结论采用双环醇联合多烯磷脂酰胆碱治疗方案,可有效调节甲亢性肝损伤患者的肝功能及血脂水平,提升临床疗效。

Efficacy of bicyclol combined with polyene phosphatidylcholine in the treatment of hyperthyroid liver injury

Objective To study the efficacy of bicyclol combined with polyene phosphatidylcholine in the treatment of hyperthyroid liver injury.Methods A total of 87 patients with hyperthyroid liver injury were divided into combination group(45 cases)and single group(42 cases)by different treatment methods.The combination group was treated by bicyclol combined with polyene phosphatidylcholine regimen,and the single group was treated by polyene phosphatidylcholine regimen.The serum indexessuperoxide dismutase(SOD),thyroglobulin antibody(TGA),thyroid microsomal antibody(TMA),human thyroglobulin(HTG),total bilirubin(TBIL),glutamate aminotransferase(ALT),aspartate aminotransferase(AST),glutamyl transpeptidase(GGT)]and therapeutic effect were compared between the two groups.Results After treatment,the SOD(246.93±90.03)ng/ml in the combination group was higher than(209.04±76.16)ng/ml in single group,and,TGA,TMA and HTG were(19.56±11.03)%,(20.01±13.88)%and(8.25±7.09)ng/ml respectively,which was lower than(24.21±9.16)%,(26.35±14.03)%and(14.95±8.74)ng/ml in single group.Their difference was statistically significant(P<0.05).After treatment,the levels of ALT,AST,GGT and TBIL were(48.6±11.5)U/L,(52.4±8.8)U/L,(61.3±16.2)U/L and(22.4±9.8)mmol/L respectively in the combination group,which was lower than(55.8±11.3)U/L,(56.9±9.8)U/L,(78.2±11.5)U/L and(30.4±12.5)mmol/L respectively in single group,and their difference was statistically significant(P<0.05).The total effective rate of treatment was 91.11%in combination group,which was higher than 61.90%in single group,and the difference was statistically significant(P<0.05).Conclusion The combination of bicyclol and polyene phosphatidylcholine can effectively regulate the liver function and blood lipid level of patients with hyperthyroid liver injury,and improve the clinical effect.