| 三种黑素瘤动物模型的建立 |
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| 引用本文： | 康恺,李运曼,蒋轶,方伟蓉.三种黑素瘤动物模型的建立[J].药学进展,2006,30(7):326-329. |
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| 作者姓名： | 康恺 李运曼 蒋轶 方伟蓉 |
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| 作者单位： | 1. 北京斯泰康生物技术有限公司,北京,102206
2. 中国药科大学生理教研室,江苏,南京,210009 |
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| 摘 要： | 目的：建立黑素瘤动物模型，用于抗黑素瘤药物的疗效评价。方法：分别通过皮下、静脉和腹腔注射方式，将B16F10黑素瘤细胞接种于小鼠体内，建立3种黑素瘤及其肺转移小鼠模型，并以达卡巴嗪作为试药，考察其对这3种模型小鼠的作用。结果：成功建立了小鼠皮下、肺转移及腹腔黑素瘤模型。达卡巴嗪对3种模型均有明显的治疗作用。结论：这3种黑素瘤动物模型可综合用于新药的临床前评价。
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| 关 键 词： | 黑素瘤 小鼠模型 B16F10细胞株 达卡巴嗪 |
| 文章编号： | 1001-5094（2006）07-0326-04 |
| 收稿时间： | 2006-04-17 |
| 修稿时间： | 2006年4月17日 |
Establishment of Three Melanoma Animal Models |
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| KANG Kai,LI Yun-man,JIANG Yi,FANG Wei-rong.Establishment of Three Melanoma Animal Models[J].Progress in Pharmaceutical Sciences,2006,30(7):326-329. |
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| Authors: | KANG Kai LI Yun-man JIANG Yi FANG Wei-rong |
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| Institution: | 1.Beijing Starvax Biotechnology Incorporation, Beijing 102206, Chian ; 2.Department of Physiology, China Pharmaceutical University, Nanfing 210009, China |
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| Abstract: | Objective: To establish melanoma animal models for the evaluation of efficacy of anti-melanoma drugs.Methods: B16F10 melanoma cells were inoculated,sc,iv and ip respectively into mice to establish 3 melanoma and lung metastasis models.Effect of DTIC,an anti-melanoma drug,on the 3 animal models was investigated.Results: The subcutaneous,lung metastatic and abdominal melanoma mouse models were well established.The significant therapeutic effects of DITC on the 3 animal models were shown.Conclusion: The 3 animal models can be comprehensively used to evaluate the efficacy of new drugs. |
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| Keywords: | Melanoma Mouse model B16F10 cell line DTIC |
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