| 3-羟基-4-甲氧基苯乙酸的合成及其抗氧化活性 |
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| 引用本文： | 张建革,闻韧.3-羟基-4-甲氧基苯乙酸的合成及其抗氧化活性[J].郑州大学学报(医学版),2004,39(2):261-263. |
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| 作者姓名： | 张建革 闻韧 |
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| 作者单位： | 郑州大学药学院,郑州,450052;复旦大学药学院,上海,200032;复旦大学药学院,上海,200032 |
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| 基金项目： | 国家自然科学基金资助项目298-72029，国际合作项目 20010140417 |
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| 摘 要： | 目的：研究3—羟基—4—甲氧基苯乙酸的合成及其抗氧化活性。方法：由异香草醛和罗丹宁缩合再经一系列的反应合成，利用DPPH自由基清除法测定其抗氧化活性。结果：该方法合成3—羟基—4—甲氧基苯乙酸的总收率59．6％，且该化合物有一定的抗氧化活性。结论：该方法避免使用剧毒氰化物，保护了环境，便于推广。
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| 关 键 词： | 3-羟基-4-甲氧基苯乙酸 异香草醛 罗丹宁 合成 活性 |
| 修稿时间： | 2003年5月6日 |
Studies on synthesis and anti-oxidation activities of (3-hydroxy-4-methoxy phenyl) acetic acid |
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| ZHANG iange,WEN Ren
School of Pharmacy,Zhengzhou University,Zhengzhou School of Pharmacy,Fudan University,Shanghai.Studies on synthesis and anti-oxidation activities of (3-hydroxy-4-methoxy phenyl) acetic acid[J].Journal of Zhengzhou University: Med Sci,2004,39(2):261-263. |
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| Authors: | ZHANG ]iange WEN Ren
School of Pharmacy Zhengzhou University Zhengzhou School of Pharmacy Fudan University Shanghai |
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| Institution: | ZHANG ]iange,WEN Ren
School of Pharmacy,Zhengzhou University,Zhengzhou 450052 School of Pharmacy,Fudan University,Shanghai 200032 |
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| Abstract: | Aim : To study on synthesis and anti-oxidation activities of ( 3-Hydroxy-4-methoxy phenyl) acetic acid. Method: ( 3-Hydroxy-4-methoxy phenyl) acetic acid were synthesized from isovanillin and rodanine via condensation, hydro-Lysis,hydroxylation,acelation and so on, and its anti-oxidation activities was studied by DPPH radical scavenging method. ResultS:(3-Hydroxy-4-methoxy phenyl) acetic acid was synthesized with an overall yield of 59. 6% , and it showed anti-oxidation activities by DPPH radical scavenging method. Conclusion: The synthesis method could be easy to popularize because it would protect environment for avoiding to use toxic cyanide. |
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| Keywords: | (3-hydroxy-4-methoxy phenyl) acetic acid isovanillin rodanine synthesis anti-oxidation activities |
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