| 锂诱发甲状腺功能减退的机制研究 |
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| 引用本文： | 戴赓孙 叶庆林. 锂诱发甲状腺功能减退的机制研究[J]. 中华内分泌代谢杂志, 1995, 11(3): 154-156 |
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| 作者姓名： | 戴赓孙 叶庆林 |
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| 作者单位： | 福建医学院检验系，福建医学院基础医学部，福建医学院医学系 |
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| 摘 要： | 对锂诱发甲状腺功能减退的机制进行了研究。结果表明５ｍｍｏｌ／Ｌ氯化锂对甲状腺细胞内ＴＳＨ刺激的ｃＡＭＰ累积有抑制作用（Ｐ＜０．００５），对ＴＳＨ引起甲状腺细胞内游离钙升高反应亦有抑制作用（Ｐ＜０．０１）。提示锂可能抑制甲状腺细胞内腺苷酸环化酶－ｃＡＭＰ和钙两种主要信号途径，导致甲状腺功能减退。
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| 关 键 词： | 甲状腺功能减退，锂，cAMP，钙，促甲状腺激素 |
A STUDY ON MECHANISM OF LITHIUM-INDUCED HYPO THYROIDISM |
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| Dai Geng-sun,Ye Qing-lin,Ye Yong-hui. A STUDY ON MECHANISM OF LITHIUM-INDUCED HYPO THYROIDISM[J]. Chinese Journal of Endocrinology and Metabolism, 1995, 11(3): 154-156 |
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| Authors: | Dai Geng-sun Ye Qing-lin Ye Yong-hui |
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| Affiliation: | Dai Geng-sun,Ye Qing-lin,Ye Yong-hui Department of Medical Laboratory Science,Fujian Medictzl Colleke,Fuzhou 350004 |
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| Abstract: | The mechanism of lithium-induced hypothyroidism was studied.The effect of lithium on thyroid cells resulted in significant inhi-bition of agonist-stimulated cAMP accumulation. The inhibition was dose-dependent for lithium. The reaction of TSH-induced in-crease in intracellular free calcium in thyroid cells was also inhibited by lithium. The results suggested that the lithium-induced hy-pothyroidism might be caused by the inhibitory effects of lithium on the principal Intracellular signalling pathways(the adenylate cy-clase-cAMP signalling pathway and the calcium signalling pathway)in thyroid cells. |
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| Keywords: | Hypothyroidism Lithium cAMP Intracellular free calcium Thyrotrophin |
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