吉西他滨、顺铂动静脉联合化疗治疗晚期非小细胞肺癌的近期疗效分析

目的 探讨选择性经支气管动脉灌注(BAI)吉西他滨、顺铂结合吉西他滨静脉化疗治疗晚期非小细胞肺癌(NSCLC)的近期疗效;方法 随机选择60例经病理证实的原发性晚期NSCLC初治病例行GP方案(吉西他滨 1 000 mg/m2 BAI d1,顺铂 50 mg/m2 BAI d1;吉西他滨1 000 mg/m2 静脉滴注 d8)治疗.结果 在可评价的60例患者中,CR 3例,PR 35例,SD 17例,PD 5例,总有效率63%.其中腺癌22例,有效率45%;鳞癌38例,有效率74%(P ＜ 0.05);中央型37例,有效率73%;周围型23例,有效率48%(P ＜ 0.05).结论 GP方案经动静脉联合化疗治疗晚期NSCLC的近期效果确切,疗效与肿瘤的解剖部位、病理分型有明显相关性.

Bronchial artery infusion of Gemcitabine and Cisplatin combined with systemic chemotherapy for advanced non-small cell lung cancer: its short-term efficacy

Objective To assess the short-term efficacy of bronchial artery infusion(BAI) of Gemcitabine(GEM) plus Cisplatin(DDP) combined with systemic chemotherapy of GEM for advanced nonsmall cell lung cancer(NSCLC).Methods A total of 60 patients with pathologically proved primary NSCLC were randomly selected.BAI with GEM(1 000 mg/m~2) and DDP(DDP 50 mg/m~2) was performed on the first day,and systemic chemotherapy of GEM(1 000 mg/m~2) was carried out on the eighth day.The clinical results were analyzed.Results Of the 60 patients,CR,PR,SD and PD were obtained in 3,35,17 and 5, respectively,with an overall effective rate of 63%.Twenty-two patients had adenocarcinoma and the effective rate of them was 45%.Thirty-eight patients had squamous cell carcinoma and their effective rate was 74%. The difference in the effective rate between the above two pathologic types was significant(P<0.05).Central type lung cancer was seen in 37 cases,their effective rate was 73%.The peripheral type lung cancer was seen in the remaining 23 patients and the effective rate was 48%.The difference in the effective rate was statistically significant between the central type and the peripheral type(P<0.05).Conclusion The combination of bronchial artery infusion with systemic chemotherapy by using GP plan is an effective,feasible approach in the treatment of advanced non-small cell lung cancer.The short-term efficacy of the treatment bears a close relationship to the anatomical location and pathological type of the cancer.