Rho/Rho激酶信号通路与支架内再狭窄的研究

血管支架作为一种有效治疗心脑血管硬化手段得到广泛的研究和应用。血管支架内再狭窄的发生难以避免。支架内再狭窄是由血管平滑肌分化、迁移,细胞外基质的过度生成所致的病理生理过程。Rho激酶参与支架植入引起的新生内膜增生的调节。长期抑制Rho激酶的表达可阻止新生内膜的增生,可能成为防止支架内再狭窄的一种方法。

Studies on Rho/Rho-kinase signalling pathways and in-stent restenosis

As an effective treatment for cardiac and cerebral angiosclerotic disorders,intravascular stent placement has been widely employed in researches and clinical practice.However,the occurrence of instent restenosis is still a serious problem which is hardly to be avoided.Rho-kinase regulates VSMC proliferation and migration after stenting,and it plays an important role in the neointimal formation.Longterm inhibition of Rho-kinase can suppress the in-stent neointimal formation through multiple mechanisms. Inhibition of the Rho /Rho kinase pathway may provide a useful strategy to prevent the occurrence of in-stent restenosis.