甲状腺动脉栓塞治疗Graves病与外科切除术长期疗效比较

目的比较甲状腺动脉栓塞与传统外科甲状腺切除术治疗Graves病的长期(5年)疗效。方法选取2003年1月-2010年12月因Graves病入院行经甲状腺动脉栓塞治疗患者54例作为介入治疗组,选取同期接受外科甲状腺次全手术切除术者40例作为外科治疗组,回顾性分析两组1、3、5年治愈率、有效率(好转及治愈),并进行比较。结果1、3、5年治愈率在介入治疗组分别为68.52%、61.18%和47.88%,在外科治疗组分别为97.50%、78.54%,69.48%;有效率在介入治疗组分别为98.15%、80.48%和60.90%,在外科治疗组分别为97.50%、76.42%和67.60%经Ridit分析,两组间1、3、5年疗效差异有统计学意义(P<0.05);而甲状腺功能减退发生率两组间差异无统计学意义(P>0.05)。结论甲状腺动脉栓塞治疗Graves病后近中期疗效满意,远期效果逊于外科切除术

A comparative study of the long-term effect of thyroid arterial embolization with surgical thyroidectomy in treating Graves' disease

Objective To compare long-term(5 years) therapeutic effect of thyroid arterial embolization with surgical thyroidectomy in treating Graves’ disease.Methods A total of 54 patients with Graves’ disease,who were encountered during the period from Jan.2003 to Dec.2010 and received thyroid arterial embolization treatment,were collected and were used as interventional group.While 40 patients with Graves’ disease,who were encountered during the same period and received surgical thyroidectomy,were used as surgical group.The 1-year,3-year and 5-year cure rates and efficiency rates(improved and cure) were calculated and the results were compared between the two groups.Results The 1-year,3-year and 5-year cure rates of the interventional group were 68.52%,61.18%and 47.88%,respectively.The 1-year,3-year and 5-year cure rates of the surgical group were 97.50%,78.54%and 69.48%,respectively.The 1-year, 3-year and 5-year efficiency rates in the interventional group and in the surgical group were 98.15%, 80.48%,60.90%and 97.50%,76.42%,67.60%,respectively.By using Ridit analysis,statistically significant difference in the 1-year,3-year and 5-year cure rates and efficiency rates existed between the interventional group and the surgical group(P<0.05%),while no statistically significant difference in the occurrence of hypothyroidism existed between the two groups(P>0.05%).Conclusion For the treatment of Graves’ disease,thyroid arterial embolization has satisfactory short-term and mid-term result,although its long-term result is less effective than that of thyroidectomy.