Pyrogenicity and Immunogenicity of Lipid A Complexed with Bovine Serum Albumin or Human Serum Albumin |
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| Authors: | E. T. Rietschel, Y. B. Kim, D. W. Watson, C. Galanos, O. Lü deritz, O. Westphal |
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| Affiliation: | Department of Microbiology, The University of Chicago, Chicago, Illinois 60637 |
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| Abstract: | The lipid A component of bacterial lipopolysaccharides (endotoxins), when complexed to bovine serum albumin (BSA) or human serum albumin (HSA), was shown to be a potent pyrogen. Furthermore, rabbits could be protected against endotoxin fever by immunization with both lipid A.BSA and lipid A.HSA complexes. The results presented in this paper show that lipid A is responsible for the pyrogenic activity of endotoxins and their ability to induce pyrogenic immunity. |
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