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血清可溶性肿瘤坏死因子受体与2型糖尿病视网膜病变相关性研究
引用本文:张文博,彭媛,聂红平. 血清可溶性肿瘤坏死因子受体与2型糖尿病视网膜病变相关性研究[J]. 眼科新进展, 2016, 0(7): 662-666. DOI: 10.13389/j.cnki.rao.2016.0176
作者姓名:张文博  彭媛  聂红平
作者单位:100034 北京市,北京大学第一医院眼科,视觉损伤与修复教育部重点实验室
摘    要:目的 研究血清可溶性肿瘤坏死因子受体(solubletumornecrosisfactorreceptor,sTNFR)与2型糖尿病视网膜病变的相关性。方法 66例2型糖尿病患者通过眼底检查和眼底荧光血管造影按照EDTRS分期分为3组:无糖尿病视网膜病变(nodiabeticretinopathy,NDR;n=22)组、非增殖型糖尿病视网膜病变(nonproliferativediabeticretinopathy,NPDR;n=24)组和增殖型糖尿病视网膜病变(proliferativediabeticretinopathy,PDR;n=20)组。21名健康人作为对照组。检测4组研究对象血清中肿瘤坏死因子(tumornecrosisfactor,TNF)-α、sTNFR-1、sTNFR-2水平。组间统计分析采用非参数Mann-WhitneyU检验。结果 血清中TNF-α中位数分别为:对照组0pg·mL-1、NDR组3.45pg·mL-1、NPDR组3.92pg·mL-1、PDR组8.12pg·mL-1。对照组与PDR组(P<0.001)、NDR组与PDR组(P=0.008)比较差异均有统计学意义。血清中sTNFR-1水平中位数:对照组1.50ng·mL-1、NDR组1.88ng·mL-1、NPDR组2.58ng·mL-1、PDR组3.00ng·mL-1。对照组与NPDR组(P<0.001)、对照组与PDR组(P<0.001)、NDR组与NPDR组(P=0.007)、NDR组与PDR组(P<0.001)比较,差异均有统计学意义。血清中sT-NFR-2中位数分别为:对照组3.88ng·mL-1、NDR组5.01ng·mL-1、NPDR组5.21ng·mL-1、PDR组6.33ng·mL-1。除了NDR组与NPDR组(P=0.070)间差异无统计学意义外,其他组间差异均有统计学意义(均为P<0.05)。结论 血清中sTNFR与2型糖尿病视网膜病变密切相关,表明sTNFR在糖尿病视网膜病变的发生发展中起到了一定的作用。对sTNFR进行进一步研究可以寻找治疗糖尿病视网膜病变新的靶点。

关 键 词:糖尿病视网膜病变  肿瘤坏死因子受体  相关性研究

Association between sTNFR and diabetic retinopathy in type 2 diabetic patients
ZHANG Wen-Bo,PENG-Yuan,NIE Hong-Ping. Association between sTNFR and diabetic retinopathy in type 2 diabetic patients[J]. Recent Advances in Ophthalmology, 2016, 0(7): 662-666. DOI: 10.13389/j.cnki.rao.2016.0176
Authors:ZHANG Wen-Bo  PENG-Yuan  NIE Hong-Ping
Affiliation:Department of Ophthalmology,Peking University First Hospital, Key Laboratory of Vision Loss and RestoratLon of Ministry of Education,Beijing 100034?¬China
Abstract:Objective To investigate the associations of serum levels of soluble tumor necrosis factor receptor ( sTNFR) with diabetic retinopathy in type 2 diabetic patients. Methods A cross-sectional design was utilized for this study. 66 patients with type 2 diabetes underwent fundus exanunation or fundus fluorescein angiography according to the Early Treatment Diabetic Retinopathy Study ( EDTRS) and were divided into three groups : no diabetic retinopathy ( NDR , n = 22) ,non-proliferative diabetic retinopathy ( NPDR . n = 24 ) and proliferative diabetic retinopathy ( PDR . n = 20 ) . 21 healthy subjects were enrolled for control group. Serum levels of tumor necrosis factor ( TNF) -eL ,sTNFR-I and sTNFR-2 were analyzed. Statistical analysis was performed using nonparametric Mann-Whitney U test. Results The median serum TNF-e/ levels was 0 pg . mL-1 in control group,3. 45 pg . mL-1 in NDR group,3. 92 pg . mL-l in NPDR group and 8. 12 pg . mL-l in PDR group. Statistical significances were found between control group and PDR group (P < 0. 001) . NDR group and PDR group (P = 0. 008 ) . The median serum sTNFR-I levels was l. 50 ng . mL -l in control group , 1. 88 ng . mL -l in NDR group,2. 58 ng . mL -l in NPDR group and 3. 00 ng . mL -l in PDR group. Statistical significances were found between control group and NPDR group ( P < 0. 001 ) , control group and PDR group (P < 0. 001 ) , NDR group and NPDR group (P = 0. 007 ) . NDR group and PDR group ( P < 0. 001) . The median serum sTNFR-2 levels was 3. 88 ng ’ mL-1 in control group,5. 01 ng . mL -l in NDR group , 5. 21 ng . mL-l in NPDR group and 6. 33 ng ’ mL-l in PDR group. Statistical significances were found between all groups (P < 0. 05 ) , except between group NDR group and NPDR group (P = 0. 07 ) . Conclusion The serum levels of sTNFR-I . sTNFR-2 .TNF-e/are highly correlated with DR in type 2 diabetic patients , suggesting that sTNFR may play an important role in the development of DR. Research for sTNFR may be able to find a new therapeutic targets for DR.
Keywords:diabetic retinopathy  tumor necrosis factor receptor  correlation analysis
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