| 单核苷酸多态性与年龄相关性白内障的研究进展 |
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| 引用本文： | 顾珊珊,戎晗,张国伟,康丽华,管怀进.单核苷酸多态性与年龄相关性白内障的研究进展[J].眼科新进展,2016,0(7):691-696. |
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| 作者姓名： | 顾珊珊 戎晗 张国伟 康丽华 管怀进 |
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| 作者单位： | 226001 江苏省南通市，南通大学附属医院眼科 |
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| 基金项目： | 国家自然科学基金资助(编号:81470616、81270987、81500706)National Natural Science Foundation of China (81470616 |
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| 摘 要： | 年龄相关性白内障是最常见的白内障类型，也是全球首位的致盲性因素。大量研究表明，遗传因素在年龄相关性白内障发病过程中发挥着重要作用。单核苷酸多态性作为第３代分子遗传标志，是最常见的多态性表现形式，本文就近年来单核苷酸多态性与年龄相关性白内障相关性的最新研究成果作一简要综述。
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| 关 键 词： | 年龄相关性白内障 单核苷酸多态性 基因 |
Progress on single nucleotide polymorphism and age-related cataract |
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| GU Shan-Shan,RONG Han,ZHANG Guo-Wei,KANG Li-Hua,GUAN Huai-Jin.Progress on single nucleotide polymorphism and age-related cataract[J].Recent Advances in Ophthalmology,2016,0(7):691-696. |
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| Authors: | GU Shan-Shan RONG Han ZHANG Guo-Wei KANG Li-Hua GUAN Huai-Jin |
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| Institution: | Department of Ophthalmology,Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province．China |
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| Abstract: | Age-related cataract ( ARC) is the most common type of cataract and the leading cause of blindness in the world today. A large number of studies have shown that the genetic factor plays an important role in the pathogenesis of ARC. As the third generation of molecular genetic marker , single nucleotide polymorphism is the commonest polymorphic form of human. This article reviews the recent literature concerning the SNP and the newest progress of research on ARC. |
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| Keywords: | age-related cataract single nucleotide polymorphism gene |
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