高血压脑出血手术后深静脉血栓栓塞症预防性治疗

目的 评估高血压脑出血病人在围手术期皮下注射低剂量低分子肝素结合穿戴弹力袜预防深静脉血栓栓塞症的安全性及有效性.方法 采用随机分组的方法,将符合条件的60例高血压脑出血患者分为预防组和对照组.预防组32例,术后第1天至14天皮下连续注射低分子肝素0.2 ml/d,同时穿戴弹力袜.对照组28例,未行抗凝措施和穿戴弹力袜.两组患者于术后1 d,7 d和14 d分别行双下肢深静脉彩色超声多普勒检查,观察下肢深静脉血栓发生情况.术后1 d和7 d复查头颅CT,术后每天监测血小板计数和凝血功能.结果 预防组32例无一例下肢深静脉血栓形成.对照组28例发生下肢深静脉血栓8例(28.6%),其中6例(21.4%)发生在瘫痪侧,7例(25.0%)发生在脑静脉以下,有症状者2例(7.1%),经溶栓或抗凝治疗好转;发生症状性肺栓塞1例(3.6%).两组血小板计数和凝血功能差异无统计学意义(P>0.05),术后发生颅内出血各1例,经再次手术,病情均稳定.两组间术后再出血差异无统计学意义,而下肢深静脉血栓形成和肺栓塞发生率存在统计学差异(深静脉血栓28.6% vs 0,P

Prophylactic treatment for deep vein thrombosis after hypertensive intracerebral hemorrhage operation using low dose of low-molecular-weight heparin combined with compression stockings

Objective To assess the safety and availability of low dose of low-molecular-weight heparin combined with compression stockings for venous thromboembolism in patients with hypertensive intracerebral hemorrhage after operation. Methods Sixty patients of hypertensive intracerebral hemorrhage were randomly divided into 2 groups:prophylactic group(n=32)and control group(n=28).The patients in prophylactic group were injected hypodermically with low-molecular-weight heparin(0.2 ml/d)from day 1 to day 14 after ope...