Neuropathy in diabetic BB/Wor rats treated with insulin implants |
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Authors: | S Mohseni Claes Hildebrand |
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Institution: | Department of Biomedicine and Surgery, Division of Cell Biology, Faculty of Health Sciences, University of Link?ping, S-581 85 Link?ping, Sweden Tel.: +46-13-22-41-44, Fax: +46-13-22-31-92, SE
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Abstract: | To elucidate the pathophysiology of diabetic neuropathy many workers have examined nerve specimens from diabetic rats. While
most workers found that animals with high blood glucose levels develop neuropathy, some researchers report that the peripheral
nerves are normal in hyperglycaemic rats. Hypoglycaemia may also cause neuropathy. Some workers suggest that neuropathy is
linked to fluctuations of the blood glucose level. In the present study we examine plantar nerves of diabetic BB/ Wor rats
maintained on an eu-/hyperglycaemic or an eu-/ hypoglycaemic regime with insulin implants. Treatment with implants worked
well. Light microscopic examination of nerve fibres in non-diabetic control rats and in eu-/ hyperglycaemic diabetic rats
showed a normal picture. Preparations from eu-/hypoglycemic rats showed irregular myelin sheaths and signs of Wallerian degeneration.
The lengths and diameters of the largest internodes were significantly subnormal. We conclude, that periodic moderate hypoglycaemia,
but not periodic moderate hyperglycaemia, elicits neuropathy in diabetic BB/Wor rats treated with insulin implants.
Received: 5 December 1997 / Revised, accepted: 3 February 1998 |
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Keywords: | Neuropathy Hypoglycaemia Hyperglycaemia Insulin BB/Wor rat |
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