Brazilin augments cellular immunity in multiple low dose streptozotocin (MLD-STZ) induced type I diabetic mice |
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Authors: | Kyoung-Mee Yang Sun-Duck Jeon Dhong-Soo So Chang-Kiu Moon |
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Institution: | College of Pharmacy, Seoul National University, Kwanak-ku, Korea. |
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Abstract: | Brazilin, an active principle of Caesalprenia sappan, was examined for its immunopotentiating effects in multiple low dose streptozotocin (MLD-STZ) induced type diabetic mice. Brazilin was intraperitoneally administered for 5 consecutive days to MLD-STZ induced type I diabetic mice. Delayed type hypersensitivity, Con A-induced proliferation of splenocytes and mixed lymphocyte reaction, which had been decreased in diabetic mice, were significantly recovered by the administration of brazilin. Brazilin increased IL-2 production without affecting suppressor cell activity. Con A-induced and IL-2-induced expression of high affinity IL-2 receptors were also enhanced by brazilin. These results indicate that brazilin augments cellular immune responses, which are suppressed in the MLD-STZ induced type I diabetic mice, by increasing IL-2 production and responsiveness of immune cells to IL-2. |
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Keywords: | Brazilin Immunomodulating agents Type I diabetes Delayed type hypersensitivity Mixed lymphocyte reaction Proliferation Splenocytes IL-2 |
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