乙肝病毒和黄曲霉毒素与肝癌发生的关系

目的 探讨乙型肝炎病毒（ＨＢＶ）和黄曲霉素素（ＡＦ）与肝癌发生的关系。方法 对５６２例ＨＢｓＡｇ阳性的肝癌高危人群和７１９例ＨＢｓＡｇ阴性的对照人群进行１０年前瞻观察，同时采用抗ＡＦＭ１高亲和力的单克隆抗体系统，以免疫浓和高压液相（ＨＰＬＣ）系列测定由２５例肝癌和１２５例非肝癌对象组成的病例对照人（１：５）尿中ＡＦＭ１排出量。结果 （１）ＨＢｓＡｇｂｊ ｎｔｇ ｘｅｇ ｅｆｈ ｕｋｋｍｗ ｒｈ ｆ

The Relation between Hepatitis B Virus Infection or Aflatoxin Exposure and the Incidence of Primary Liver Cancer

[Purpose]To investigate the relation between hepatitis B virus(HBV) infection or aflatoxin(AF) exposure and the incidence of primary liver cancer(PLC). [Methods] A ten-year prospective case-control study including 562 HBsAg carries and 719 HBsAg negative cases was carried out by immuine concentration and high pressure liguid chromatography (HPLC) using the high affinity anti-AFM1 monoclonal antibody system.The values of AFM1 in urine among the case-control population (ration 1:5)including 25 PHC cases and 125 non-PHC cases were measured.[Results] (1)The average year-incidene rate of PLC was 910. 89/100000 (46/5050) in the HBsAg positive group and its RR was 37. 85-fold of that in control group(24.24/100000,1/4126). (2)The values of AFM1 in urine among 52. 67% (79/150) were over 5 ng/L and the values of urine AFM1 in the PHC patients(80%,20/25)were significantly higher than those in the control cases (47.20%,59/125, P < 0.001). [Conclusion]HBV infection and AF exposure are important etiological factors in the development of PLC and both result in carinogenic syneny.