雌激素受体与食管癌临床病理特性的关系

探讨雌激素受体表达与食管鳞状细胞癌临床病理的关系。方法 用免疫组织化学方法检测了４７例林县食管癌组织中ＥＲ的表达。结果 ４７例食管癌标本中,ＥＲ阳性者１９例,其表达率为４０．４％;生存期大于５年组与小于５年组相比,ＥＲ阳性率为２８．６％和５７．９％,具有显著性差异,与性别,癌组织分化程度及有无淋巴结转移无关。

Relationship between Expression of Estrogen Receptor and Clinical Pathological Features in Esophageal Squamous Cell Carcinoma

[Purpose] To ascertain relationship between clinical pathological features and estrogen receptor (ER). [Method] Immunohistochemical detection of ER was performed in 47 an of Linxian esophageal squamous cell carcinoma (ESCC). [Results] Positive ER was seen in 19 of the 47 patients with esophageal cancer (40.4% ). ER positive was 28. 6% in patient survival longer than 5 years , 57.9% in patient survival less than 5 yare. There was significant difference between the two groups (P < 0. 05.). However, there was no significant correlation with the sex , histologic grade, and lymphatic spread .[Conclusion] It is indicated that carcinogenesis of esophageal carcinoma might be related to sex hormone metablism . The results suggest that ER positive ESCC has worse pronosis than ER negative ESCC.